Uganda Research Hub
- Adjunctive Sertraline for the Treatment of Cryptococcal Meningitis (ASTRO-CM)
PI: David Boulware, Co-I: David Meya, Josh Rhein.
This randomized clinical trial tests the anti-fungal activity of sertraline (a SSRI anti-depressant) for cryptococcal meningitis.
- Dr. Josh Rhein is a UMN assistant professor located on site in Kampala, Uganda
- Dr. Meya's YouTube video on burden of cryptococcal disease
- Operational Research for Cryptococcal Antigen Screening (ORCAS)
PIs: David Meya, David Boulware, Co-I's: Radha Rajasingham, Kathy Hullsiek
This randomized clinical trial tests improved therapy for asymptomatic cryptococcal antigenemia in order to reduce AIDS related mortality. YouTube video on point-of- care CRAG testing.
- Refugee Health Screening Program Evaluation and Disease Surveillance
PI: Bill Stauffer; in collaboration with CDC and Int'l Organization for Migration (IOM) allows for program evaluation in Congolese refugee camps in Uganda. Other global locations exist.
- Uptake of and barriers to HPV vaccination among adolescent girls in rural Uganda
PI: Nicole Basta; Co-I: Cecily Banura, Shalini Kulasingam; UMN AHC Seed Grant
This pilot project in collaboration with School of Public Health assesses vaccine uptake.
- Emerging Pandemic Threats 2 Program, USAID Cooperative Agreement
PI: Katey Pelican. This supports epidemiologic surveillance studies of emerging pandemic threats in Sub-Saharan Africa through a network of universities. Hub activities are in Uganda.
- Optimizing iron status while minimizing morbidity for HIV-infected Ugandan children
PI: Sarah Cusick; This study aims to determine optimal methods of iron therapy in children with iron deficiency and/or anemia of chronic disease. Award from Masonic Children's Foundation.
- Assessing antiretroviral distribution in CNS reservoirs using IR-MALDEI mass spectrometry
PI: Melanie Nicol; Co-I: David Meya, Josh Rhein, David Boulware. UMN AHC Seed Grant
This project investigates HIV medication spatial distribution on a cellular level in brain tissue from autopsy specimens from ASTRO-CM clinical trial participants.
- Phased Implementation of Cryptococcal Screening in South Africa
PIs: Nelesh Govender, David Boulware; Co-I’s: Radha Rajasingham, Tom Chiller
This project will roll out cryptococcal antigen screening and preemptive antifungal therapy among HIV-infected persons living with AIDS nationwide in South Africa in collaboration with the South African National Institute of Communicable Diseases and U.S. CDC.
- HIV-associated Myocardial Fibrosis, in collaboration with Univ. of Cape Town
PIs: Jason Baker, Mpiko Ntsekhe Co-I’s: Ntobeko Ntusi, Graeme Meintjes, D Boulware
This pilot project investigates the interaction of HIV and cardiovascular disease in a cohort combining investigations in cardiac MRI with immunologic profiling. Minneapolis Medical Research Foundation supported pilot. R01 and AHA grants submitted.
- Assessing impact of Emergency Medicine implementation in Arusha, Tanzania
- Sensitivity of lung ultrasound in children with radiographic pneumonia.
PI: Stephen Dunlop; Co-I, Nate Herr, Michael Rhodes. These are quality improvement initiatives aiming at improving care in a resource-limited setting. Dr. Dunlop's Grand Rounds Lecture.
- Prevalence of Schistosoma haematobium among obstetric fistula patients and impact of infection on fistula characteristics and surgical outcomes
PI: Kristin Chrouser; Co-I: Peter Melchert
- Sero-epidemiology of arboviruses and correlates of protection, Armed Forces Research Institute Medical Sciences (AFRIMS), Walter Reed Army Institute of Research.
PI: Katie Anderson, MD PhD; Dr. Anderson conducts epidemiologic field studies of dengue and other arboviruses in Thailand via AFRIMS, spending 6 month/year on site in Bangkok. Zika transmission is a new field research project in 2016.
- HIV NIH clinical trials networks in Nanning, China, 2UM1AI069530-08
PI: Brooks Jackson; An HIV clinical trials site in Nanning, China allows Chinese-speaking U.S. medical opportunities for HIV research at center affiliated with NIH HIV clinical trials networks for HIV prevention (HPTN), preventing mother-to- child transmission (IMPAACT)
- Study Implementation Protocol: Factors associated with longevity in Guangxi, China
PI: Fang Yu PhD; Study investigates factors associated with longevity and functional independence among Chinese centenarians in Guangxi.
- Novel Therapeutic Treatment of Hepatitis B Virus Infection
PI: Louis Mansky
- Differential miRNA profiles between HCC cases and controls, among individuals infected with HBV with BCP double mutations.
PI: Guisheng Song
- Secondhand smoke exposure and carcinogen uptake in elementary school children in Nanning, Guanxi.
PI: Irina Stepanov
- Epidemiology and Outcomes of Hepatitis E in immunocompromised hosts in Argentina
- Fatty Liver and Fibrosis during immune reconstitution of HIV-infected patients in Argentina
PI: Jose Debes; Co-I’s: Domingo Balderramo, Viviana Re. This translational hepatology research is located at Hospital Rawson, Hospital Privado, and Instituto de Virologia, in Cordoba, Argentina. Support via: American College of Gastroenterology (ACG-CR- 033-2016) and Robert Wood Johnson Foundation.
- Etiologies of Febrile illness in Rural Archipelago of Bocas del Toro, Panamá.
PI: Jonathan Kirsch in collaboration with Floating Doctors, NGO. This project seeks to define etiologies of febrile illness and to implement a diagnostic testing algorithm using point-of- care testing strategies. Project is supported through philanthropic gift via Univ of MN Foundation.