Research Projects

Uganda Research Hub

Uganda Research Hub

  • Adjunctive Sertraline for the Treatment of Cryptococcal Meningitis (ASTRO-CM)
    PI: David Boulware, Co-I: David Meya, Josh Rhein.
    This randomized clinical trial tests the anti-fungal activity of sertraline (a SSRI anti-depressant) for cryptococcal meningitis. 
    • Dr. Josh Rhein is a UMN assistant professor located on site in Kampala, Uganda
    • Dr. Meya's YouTube video on burden of cryptococcal disease

  • Operational Research for Cryptococcal Antigen Screening (ORCAS)
    PIs: David Meya, David Boulware, Co-I's: Radha Rajasingham, Kathy Hullsiek
    This randomized clinical trial tests improved therapy for asymptomatic cryptococcal antigenemia in order to reduce AIDS related mortality. YouTube video on point-of- care CRAG testing. 

  • Refugee Health Screening Program Evaluation and Disease Surveillance
    PI: Bill Stauffer; in collaboration with CDC and Int'l Organization for Migration (IOM) allows for program evaluation in Congolese refugee camps in Uganda. Other global locations exist. 

  • Uptake of and barriers to HPV vaccination among adolescent girls in rural Uganda
    PI: Nicole Basta; Co-I: Cecily Banura, Shalini Kulasingam; UMN AHC Seed Grant 
    This pilot project in collaboration with School of Public Health assesses vaccine uptake.

  • Emerging Pandemic Threats 2 Program, USAID Cooperative Agreement
    PI: Katey Pelican. This supports epidemiologic surveillance studies of emerging pandemic threats in Sub-Saharan Africa through a network of universities. Hub activities are in Uganda.

  • Optimizing iron status while minimizing morbidity for HIV-infected Ugandan children
    PI: Sarah Cusick; This study aims to determine optimal methods of iron therapy in children with iron deficiency and/or anemia of chronic disease. Award from Masonic Children's Foundation.

  • Assessing antiretroviral distribution in CNS reservoirs using IR-MALDEI mass spectrometry
    PI: Melanie Nicol; Co-I: David Meya, Josh Rhein, David Boulware. UMN AHC Seed Grant
    This project investigates HIV medication spatial distribution on a cellular level in brain tissue from autopsy specimens from ASTRO-CM clinical trial participants.

South Africa

Tanzania

  • Assessing impact of Emergency Medicine implementation in Arusha, Tanzania
  • Sensitivity of lung ultrasound in children with radiographic pneumonia.
    PI: Stephen Dunlop; Co-I, Nate Herr, Michael Rhodes. These are quality improvement initiatives aiming at improving care in a resource-limited setting. Dr. Dunlop's Grand Rounds Lecture.

  • Prevalence of Schistosoma haematobium among obstetric fistula patients and impact of infection on fistula characteristics and surgical outcomes 
    PI: Kristin Chrouser; Co-I: Peter Melchert

Thailand

  • Sero-epidemiology of arboviruses and correlates of protection, Armed Forces Research Institute Medical Sciences (AFRIMS), Walter Reed Army Institute of Research.
    PI: Katie Anderson, MD PhD; Dr. Anderson conducts epidemiologic field studies of dengue and other arboviruses in Thailand via AFRIMS, spending 6 month/year on site in Bangkok. Zika transmission is a new field research project in 2016.

China

  • HIV NIH clinical trials networks in Nanning, China, 2UM1AI069530-08
    PI: Brooks Jackson; An HIV clinical trials site in Nanning, China allows Chinese-speaking U.S. medical opportunities for HIV research at center affiliated with NIH HIV clinical trials networks for HIV prevention (HPTN), preventing mother-to- child transmission (IMPAACT)

  • Study Implementation Protocol: Factors associated with longevity in Guangxi, China
    PI: Fang Yu PhD; Study investigates factors associated with longevity and functional independence among Chinese centenarians in Guangxi.

  • Novel Therapeutic Treatment of Hepatitis B Virus Infection
    PI: Louis Mansky

  • Differential miRNA profiles between HCC cases and controls, among individuals infected with HBV with BCP double mutations.
    PI: Guisheng Song

  • Secondhand smoke exposure and carcinogen uptake in elementary school children in Nanning, Guanxi.
    PI: Irina Stepanov

Latin America

  • Dengue Fever in Colombia: Improving Diagnosis
    PI: Jonathan Kirsch
    This Doris Duke fellowship site at University of the Valley (UniValle) and Hospital Universitario del Valle (HUV). Cali, Colombia will enable fellows to gain experience in the following clinical research activities: Chart review, clinical site visits, statistical analysis of data from charts and collaborative work to create new diagnostic criteria. Spanish language skills are a requirement for consideration.

  • Intervention-based Family Medicine Research in Chile
    PI: Diego Garcia-Huidobro
    Current research activities include: "Development and evaluation of a parenting intervention to prevent illicit substances among Chilean youth" and "Needs assessment of family members receiving care in hospital units." Both of these projects aim to develop interventions that include the family as a unit of health. Doris Duke ICRF applicants may contact Dr. Garcia-Huidobro directly to discuss potential research activities for fellowship year.

  • Epidemiology and Outcomes of Hepatitis E in Immunocompromised Hosts in Argentina
    PI:
    Jose Debes

  • Fatty Liver and Fibrosis During Immune Reconstitution of HIV-infected Patients in Argentina
    PI: Jose Debes; Co-PI’s: Domingo Balderramo, Viviana Re
    This translational hepatology research is located at Hospital Rawson, Hospital Privado, and Instituto de Virologia, in Cordoba, Argentina. Support via: American College of Gastroenterology (ACG-CR- 033-2016) and Robert Wood Johnson Foundation.

  • Etiologies of Febrile Illness in Rural Archipelago of Bocas del Toro, Panamá
    PI: Jonathan Kirsch in collaboration with Floating Doctors, NGO
    This project seeks to define etiologies of febrile illness and to implement a diagnostic testing algorithm using point-of-care testing strategies. The project is supported through philanthropic gift via Univ of MN Foundation.