Christine Wendt, MD

Academic Title

Professor of Medicine

Clinic Title(s)
  • Pulmonologist
  • Intensivist

Medical School: University of Minnesota

Residency: University of Minnesota

Fellowship: University of Minnesota

  • COPD
  • lung cancer
  • proteomics
  • metabolomics
  • microbiome

Professional Memberships and Affiliations

  • American Thoracic Society
Awards and Recognition Received
  • Mentor of the Year UMN CTSI (2016)
  • Voted Top Doctors in Minnesota (2009-2012)
  • Teacher of the Year Award, Department of Medicine, University of Minnesota (1999)

Biography Summary

Chris Wendt, MD is a Professor of Medicine and Section Chief of Pulmonary, Allergy, Critical Care and Sleep Medicine at the Minneapolis VAMC. Dr. Wendt's academic career has focused on laboratory, translational, and clinical investigation related to chronic obstructive pulmonary disease (COPD). Dr. Wendt's laboratory focuses on biomarkers and pathways of disease in COPD using a trans-omic approach. Recent collaborations include the study of lung structure and function regarding airflow and particle deposition in COPD. Current clinical studies include the genetic basis of COPD and the role of the microbiome in COPD. Dr. Wendt has been funded by the NIH continuously for over 20 years period and currently is involved in multiple studies, both clinical and translational, in COPD. Dr. Wendt has authored or co-authored more than 65 peer-reviewed publications.

Research Summary

Dr. Wendt's research has focused on biomarkers of disease using high-throughput mass spectrometry, specifically focusing on chronic obstructive lung disease, both COPD and BOS following lung transplantation. Dr. Wendt has a long-standing interest in clinical and translational research in COPD. Dr. Wendt has participated on three large NIH COPD trials and currently am identifying biomarkers and causal pathways in COPD using a mulit-omic approach including transcriptomics, proteomics, metabolomics, computational and systems biology. This includes COPD, HIV associated COPD and COPD as a causal pathway to lung cancer. In regards to COPD we have identified peptides, i.e. signs of protease activity, tryptophan catabolism and sphingolipids as biomarkers of COPD. Lastly, Dr. Wendt's research is also focusing on the role of the microbiota in COPD pathogenesis and progression.

Clinical Interests
  • COPD
  • Lung Cancer
Board Certifications
  • Pulmonary
  • Critical Care
  • Internal Medicine

Minneapolis Veterans Affairs Healthcare Systems