Alexa Pragman, MD, PhD

Post-doctoral Researcher and UMPhysician

Education

Medical School: UMN
Bachelor's: Macalester College
PhD: UMN

Administrative Contact

General Information
E: IDIM
P: (612) 624-9996
F: (612) 625-4410

Mailing Address
Minneapolis VA Health Care System
One Veterans Drive
Minneapolis, MN 55417

Bio Statement

Dr. Pragman completed her MD and PhD (Microbiology) degrees at the University of Minnesota in 2007. She completed her residency training in Internal Medicine at the University of Chicago in 2009 and completed her Infectious Disease fellowship training at the University of Minnesota in 2012. Upon completing her training, she joined University of Minnesota Physicians as an Infectious Disease physician in 2012. She works at the Delaware St. Clinic at the University of Minnesota, with clinical interest in general infectious diseases. Her other professional interest include research in the human microbiome, particularly the human lung microbiome in chronic inflammatory conditions.

Honors, Awards, Organizations

  • 2007: Graduating Medical Student Research Award
  • 2006: Alpha Omega Alpha
  • 2004: Dennis W. Watson Fellowship
  • 2004: Schmit-Steer Award
  • 2000: Certificate of Academic Honors in Medical School Year 1

Areas of Expertise

  • General Infectious diseases

Clinical Activities

  • Outpatient infectious disease clinic (Delaware St. Clinic)
  • Inpatient infectious disease consults

Research Interests 

  • The lung microbiome in inflammatory lung conditions (COPD, transplantation, cystic fibrosis)

Research Projects

  • 2013-2014: F&T Scholar Grant from the University of Minnesota Clinical and Translational Science Institute. PI: Alexa A. Pragman

Publications

  • Borewicz, K., A. A. Pragman*, H. B. Kim, M. Hertz, C. Wendt, R. E. Isaacson. Longitudinal Analysis of the Lung Microbiome in Lung Transplantation. *Co-first authors. 2013. FEMS Microbiology Letters, 339(1): 57-65. PMID: 23173619. Contribution: Data acquisition, analysis, statistical testing, manuscript preparation and editing.
  • Pragman, A. A., H. B. Kim, C. S. Reilly, C. Wendt, R. E. Isaacson. The lung microbiome in moderate and severe chronic obstructive pulmonary disease. 2012. PLoS One. 7(10):e47305. doi: 10.1371/journal.pone.0047305. Epub 2012 Oct 11. PMID: 23071781. Contribution: Data acquisition, analysis, statistical testing, manuscript preparation and editing.
  • Pragman, A. A., M. A. Kuskowski, J. M. Abraham, G. A. Filice. Infectious Disease Consultation for Staphylococcus aureus Bacteremia Improves Patient Management and Outcomes. 2012. Infectious Diseases in Clinical Practice, 20(4): 261-267. PMID: 23049234. Contribution: Data acquisition and analysis, statistical testing, manuscript preparation and editing.
  • Ulrich, A., M. Bastian, S. E. Cramton, K. Ziegler, A. A. Pragman, A. Bragonzi, G. Memmi, C. Wolz, P. M. Schlievert, A. Cheung, G. Doring. 2007. The staphylococcal respiratory response regulator SrrAB induces icagene transcription and polysaccharide intercellular adhesin expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditions. Molecular Microbiology, 65(5): 1276-87. PMID: 17697253. Impact Factor 5.462. Citation Index 16. Contribution: Data acquisition and analysis, manuscript editing.
  • Pragman, A. A., L. Herron-Olson, L. C. Case, V. Kapur, and P. M. Schlievert. 2007. Sequence Analysis of the Staphylococcus aureus srrAB Locus Reveals that Truncation of srrA Affects Growth and Virulence Factor Expression. Journal of Bacteriology, 189(20): 7515-9. PMID: 17693503. Impact Factor 4.013. Citation Index 4. Contribution: Data acquisition, interpretation, manuscript preparation and editing.
  • Pragman, A. A., Y. Ji, and P. M. Schlievert. 2007. Repression of Staphylococcus aureus SrrAB Using Inducible Antisense srrA Alters Growth and Virulence Factor Transcript Levels. Biochemistry, 46(1):314-21. PMID: 17198402. Impact Factor 3.368. Citation Index 11. Contribution: Data acquisition, analysis, interpretation, manuscript preparation and editing.
  • Pragman A. A. and P. M. Schlievert. 2004. Virulence Factor Regulation in Staphylococcus aureus: The Need for In Vivo Analyses. FEMS Immunology and Medical Microbiology 42(2):147-54. PMID: 15364098. Impact Factor 1.814. Citation Index 27. Contribution: Data interpretation, analysis, manuscript preparation and editing.
  • Pragman, A. A., J. M. Yarwood, T. J. Tripp, P. M. Schlievert. 2004. Characterization of Virulence Factor Regulation by SrrAB, a Two-Component System in Staphylococcus aureus. Journal of Bacteriology 186(8):2430-38. PMID: 15060046. Impact Factor 4.146. Citation Index 53. Contribution: Data acquisition, analysis, interpretation, manuscript preparation and editing.
  • McCormick, J. K., A. A. Pragman, J. C. Stolpa, D. Y. M. Leung, P. M. Schlievert. 2001. Functional Characterization of Streptococcal Pyrogenic Exotoxin J, a Novel Superantigen. Infection and Immunity, 69:1381-88. PMID: 11179302. Impact Factor 4.212. Citation Index 23. Contribution: Data acquisition, analysis, manuscript editing and review.
  • Hoye, R. C., A. S. Baigorria, M. E. Danielson, A. A. Pragman, H. A. Rajapakse. 1999. Synthesis of ElenicAcid, an Inhibitor of Topoisomerase II. Journal of Organic Chemistry, 64:2450-53. Impact Factor 3.440. Citation Index 11. Contribution: Data acquisition, manuscript editing and review.