Vascular Biology Center

.Director: Robert P. Hebbel, MD | Bio Medical Library

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Vascular diseases are major health problems and encompass the leading causes of death and disability. This category of clinical disease includes:

  • states of cardiovascular risk such as hyper-cholesterolemia, hypertension, and diabetes;
  • the systemic features of atherosclerosis, such as coronary and peripheral artery disease, and cerebrovascular disease and stroke;
  • conditions for which angiogenesis plays a role, such as wound healing and cancer, and retinal disease in diabetes, atherosclerosis and sickle disease;
  • disorders of endothelial dysfunction and vascular dysregulation, as occurs in shock, sepsis, Raynaud’s disease, and migraine;
  • primary and secondary pulmonary hypertension;
  • the sickling disorders;
  • thrombophilia and thrombotic complications such as stroke, arterial or venous thrombosis, fetal wastage, and pulmonary embolism;
  • abnormal bleeding due to inherited or acquired states such as hemophilia and disseminated intravascular coagulation;
  • inflammatory diseases that involve participation of blood and vessel wall

Research Data

Are BOEC cells more like large vessel or microvascular endothelial cells?

Aixiang Jiang, Wei Pan, Liming C Milbauer, Robert P Hebbel

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice.
Robert P. Hebbel, Gregory M. Vercellotti, Betty S. Pace, Anna N. Solovey, Rahn Kollander, Chine F. Abanonu, Julia Nguyen, Julie Vineyard, John Belcher, Fuad Abdulla, Shadé Osifuye, John W. Eaton, Robert J. Kelm Jr, Arne Slungaard

Contact information

Mailing Address
Vascular Biology Center
Division of Hematology, Oncology and Transplantation
420 Delaware Street SE, MMC 480
Minneapolis, MN 55455

Office Location
Phillips-Wangensteen Building
Suite 14-124G
516 Delaware Street SE
Minneapolis, MN 55455

Fax: (612) 625-6919