Over 50 faculty in the Division of Hematology, Oncology and Transplantation (HOT) carry out a broad range of laboratory and clinical investigations in the fields of hematology and oncology. Basic research is currently underway on the biological underpinnings of cancer, stem cell biology, sickle cell anemia, endothelial cell biology, and tumor immunology. Clinical and translational research is being conducted to develop and test novel approaches to hematopoietic stem cell transplantation, gene therapy for hematologic disorders, targeted cancer therapy, cancer immunotherapy, regenerative medicine, and chemoprevention. All of our faculty – whether basic or clinician scientist – share the common goal of translating new discoveries into better health outcomes for the individual and community.
For additional information on research activities within the HOT Division, visit faculty members' individual bio pages.
The doctors in the HOT Division are highly trained in the clinical care of adult patients with cancer or blood disorders.
Research in the HOT Division is supported by the National Institutes of Health and other peer-reviewed national organizations, by non-profit organizations such as the Masonic Cancer Research Fund, Inc., the Komen Foundation, the Children's Cancer Research Fund, by a variety of other philanthropies and generous individual donations, and by pharmaceutical agencies.
Current research activities encompass a wide range of collaborative efforts in both basic and clinical domains. Our faculty have established and led several interdepartmental research programs including the Stem Cell Institute (founded by Catherine Verfaillie, currently led by Jakub Tolar), the Hemostasis and Thrombosis Program (Mark Reding), the Vascular Biology Program (Robert Hebbel), the Breast Cancer Biology Program (Douglas Yee), and the Stem Cell Biology Program (Philip McGlave). These join the established Adult Blood and Marrow Transplantation Program (Daniel Weisdorf). HOT Division faculty (Jeffrey Miller, Douglas Yee, Carol Lange) also hold leadership positions in the Masonic Cancer Center, University of Minnesota, a NCI-designated comprehensive cancer center.