Mast Cell Disease Program Presentations and Resources

submenu

Resources

Basic information on mastocytosis is offered at the websites of The Mastocytosis Society and the U.S. National Institutes of Health

Diagnostic Criteria for Mast Cell Activation Disease

Mastocytosis: The World Health Organization's 2008 schema constitutes the globally accepted standard for diagnosing mastocytosis. One explanation of these criteria is offered here by The Mastocytosis Society.

Mast Cell Activation Syndrome. In contrast to mastocytosis, there is not yet a single globally accepted standard for diagnosing mastocytosis. Instead, at present there principally are two proposed sets of diagnostic criteria for MCAS published in the following papers: Journal of Hematology & Oncology and International Archives of Allergy and Immunology.  

Diagnostic Evaluation for Mast Cell Activation Disease

There are a number of papers published in the peer-reviewed medical literature describing approaches to diagnostic evaluation for MCAD. One recent such paper was published in the World Journal of Hematology in 2014.   

Reviews of Mast Cell Activation Disease

Mastocytosis: There are many reviews of mastocytosis published in the peer-reviewed medical literature. A review published in the New England Journal of Medicine in July 2015 may be freely available to some. A shorter review is available from The Mastocytosis Society here.

Mast Cell Activation Syndrome:short review of mast cell activation syndrome was published in Current Allergy and Clinical Immunology in 2014. A comprehensive review chapter on mast cell activation syndrome was published in 2013 (freely available for reading on-line but not printing). Also, a transcription of a grand rounds lecture on mast cell activation syndrome (including slides) given in 2011 at the University of Toronto is available at the website of The Mastocytosis Society of Canada, and a video of a grand rounds lecture on mast cell activation syndrome given in 2014 at the University of Cape Town is available at the website of the University's Division of Pediatric Allergy (see the August 6, 2014 entry under the Allergy Webinars section of this page). 

There are many reviews in the peer-reviewed medical literature about perioperative management of mast cell disease (all focused on mastocytosis, but the principles are the same for MCAS). One recent review in the literature which may be available freely to some is Dewachter et al., Anesthesiology 2014 Mar;120(3):753-9, PMID 24135579, DOI 10.1097/ALN.0000000000000031. A shorter discussion is available on the The Mastocytosis Society website.

Presentations

  • Afrin LB. Mast Cell Activation Disease: Current Concepts and Progress. Dysautonomia International 2016, July 17, 2016, Herndon, VA.
  • Afrin, LB: "Current State of Mast Cell Activation Disease Research at the University of Minnesota." Garibaldi Lecture Series, Division of Hematology, Oncology & Transplantation, January 22, 2016.
  • Afrin, LB: “The Bulk of the Iceberg Revealed: Mast Cell Activation Syndrome.” Invited grand rounds, Department of Pediatrics, Florida Hospital for Children, Orlando, Florida, December 3, 2015.
  • Afrin, LB: "The Bulk of the Iceberg Revealed: Mast Cell Activation Syndrome.” Presentation to physicians, Wellcome Collection, London, UK, October 17, 2015.
  • Afrin, LB: “Mast Cell Activation Disease: The Most Underconsidered Cause of Idiopathic Neurologic and Psychiatric Illness.” Invited grand rounds at Department of Neurogenerative Diseases, University Hospitals Bonn, Bonn, Germany, October 14, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Invited grand rounds at Middlemore Hospital, Counties Manukau Health, Auckland, New Zealand, September 10, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Invited grand rounds at Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand, September 9, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Invited grand rounds at Tauranga Hospital, Bay of Plenty District Health Board, Tauranga Hospital, Tauranga, New Zealand, September 8, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Invited presentation at Waikato District Health Board, Waikato Hospital, Waikato, New Zealand, September 4, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Invited presentation at Southern District Health Board, Invercargill Hospital, Invercargill, New Zealand, September 1, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Department of Haematology, Dunedin Hospital, Dunedin, New Zealand, August 31, 2015.
  • Afrin, LB: “Mast Cell Activation Disease: Case Discussions.” Oamaru Medical Center, Oamuru, New Zealand, August 30, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Invited grand rounds at Christchurch Hospital, Christchurch, New Zealand, August 28, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Invited presentation at Capital and Coast District Health Board, Division of Hematology/Oncology, Wellington, New Zealand, August 26, 2015.
  • Afrin, LB: “The Prevalence of Mast Cell Activation Disease: A Quintessential Challenge for the New Century.” Invited presentation at University of Otago – Wellington, Pathology Seminar, Wellington, New Zealand, August 25, 2015.
  • Afrin, LB: “Mast Cell Activation Syndrome: 2014 Update.” The Mastocytosis Society, 2014 Annual Meeting, Rochester, MN, September 19, 2014.
  • Afrin, LB: “Systemic Mast Cell Disease: Challenging Cases.” Invited discussant, 2014 Annual Congress, The Allergy Society of South Africa, Durban, South Africa, August 10, 2014.
  • Afrin, LB: “Systemic Mast Cell Disease: An Update.” Invited presentation at the 2014 Annual Congress, The Allergy Society of South Africa, Durban, South Africa, August 9, 2014.
  • Afrin, LB: “Systemic Mast Cell Disease: An Update.” Grand rounds, Division of Allergy and Immunology, University of Cape Town, Cape Town, South Africa, August 6, 2014.
  • Afrin, LB: “Systemic Mast Cell Disease: An Update.” Invited presentation at the University of Toronto Women’s College Hospital, sponsored by The Mastocytosis Society of Canada, Toronto, Ontario, Canada, June 6, 2011.