Clinical Studies

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Clinical Studies Gastro

Clostridium Difficile Infection

Clostridium Difficile Infection

This infection may not respond to antibiotic treatment alone in a significant fraction of patients. These patients typically benefit from Fecal Microbiota Transplantation, previously known as bacteriotherapy. 'Microbiota' refers to the entire microbial communities; these can be harvested from fecal material of the donors. We study the effects of this procedure on the microbial composition of fecal samples in the recipients and different aspects of host response to this procedure (PI: Dr. Alexander Khoruts).

For more information contact:
Dr. Alex Khoruts
khoru001@umn.edu

Donor Program

Donor Program

UMN Microbiota Therapeutics Program is recruiting healthy volunteers as donors of fecal material. The donors have to pass rigorous screening and testing to qualify as they need to be absolutely healthy. This is not merely a research program in microbiota therapeutics development, but a life-saving program for many recipients. Please contact fmtstudy@umn.edu if you would like to participate as a donor. (PI: Dr. Alexander Khoruts).

For more information contact:  
Dr. Alex Khoruts
khoru001@umn.edu

A Prospective Cohort Study of Interventions for Necrotizing Pancreatitis

A Prospective Cohort Study of Interventions for Necrotizing Pancreatitis

All patients undergoing treatment for necrotizing (severe) acute pancreatitis are enrolled in a prospective database involving types of interventions (endoscopic, radiologic, surgical) to assess outcomes and predictors of outcomes.

For more information contact:
Dr. Marty Freeman
freem020@umn.edu
(612) 625-8999

Evaluation of Belatacept

Evaluation of Belatacept

The purpose of this clinical research study is to evaluate the effects of belatacept, relative to tacrolimus, on the incidence of rejection, graft loss and death in subjects receiving a liver transplant. 

Download the study document

For more information contact:
Dr. John Lake
lakex009@umn.edu

Once-Daily Oral E5501 Tablets

Once-Daily Oral E5501 Tablets

The purpose of this study is to evaluate the efficacy of once-daily Oral E5501 in subjects with chronic liver diseases and thrombocytopenia prior to elective surgical or diagnostic procedures, to evaluate the safety of short-term administration of E5501 and to evaluate the pharmacokinetics (PK) of E5501.

Download the study document

For more information contact:
Dr. John Lake
lakex009@umn.edu

Reversal of Hepatorenal Syndrome Type 1 With Lucassin®

Reversal of Hepatorenal Syndrome Type 1 With Lucassin®

This study is designed to evaluate the efficacy and safety of intravenous Lucassin® (terlipressin) versus placebo for the treatment of type 1 hepatorenal syndrome (HRS) in subjects receiving standard of care albumin therapy.

Download the study document

For more information contact:
Dr. John Lake
lakex009@umn.edu

Clostridium Difficile Infection This infection may not respond to antibiotic treatment alone in a significant fraction of pati

Clostridium Difficile Infection This infection may not respond to antibiotic treatment alone in a significant fraction of pati

This study will assess the safety and efficacy of different doses of sotrastaurin when combined with tacrolimus for the prevention of acute rejection after de novo liver transplantation.

Download the study document

For more information contact:
Dr. John Lake
lakex009@umn.edu

Research ethics at the University of Minnesota

We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.

Learn more about our commitment to research ethics