Recurrent Hypoglycemia in Type 1 Diabetes
What is the Study about?
Individuals with type 1 diabetes often develop an impaired awareness of hypoglycemia (IAH), meaning they are not fully aware of having low blood glucose levels. This research study is looking to determine what happens in the brain after repeat episodes of hypoglycemia. Hypoglycemia is a serious complication of diabetes treatments and having a greater understanding of how the brain adapts to low blood sugar may help us develop better and safer ways to treat diabetes.
Eligibility to participate
You may be eligible to participate in this Study if you:
- Are between the age of 18 – 65
- Weigh less than 300 lbs
- Have type 1 diabetes for 2 - 25 years
- Have no metallic substances in your body that cannot be removed
What is involved in the Study?
This study involves 4 visits, wearing a continuous glucose monitor (CGM) sensor for up to 2 weeks and wearing an activity and sleep tracker for up to 1 week. Two of the visits will last the whole day and be done at the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota. Participants will be given an IV infusion of glucose, insulin, and potassium to lower blood sugar while in a magnetic resonance scanner (MRI). Images of the brain will be taken with the MRI and blood will be collected for additional tests.