Naloxone, Hypoglycemia, and Exercise
What is the Study about?
Currently, people with type 1 diabetes are instructed to reduce insulin doses during and after exercise because it is known that hypoglycemia (low blood sugar) can occur with exercise. However, this may not be effective for hypoglycemia that occurs many hours after exercise. The purpose of this study is to learn if naloxone can be used to treat exercise-related hypoglycemia symptoms. Naloxone is currently used as a substance abuse treatment medication but research studies have shown it to possibly be effective in modifying next-day hypoglycemia and impaired awareness of hypoglycemia. Naloxone, for this study, is considered to be an investigational drug and is not approved by the FDA for how we are using it.
Eligibility to participate
You may be eligible to participate in this Study if you:
- Are between the age of 18 – 65
- Have type 1 diabetes for 2 - 30 years
- Are willing to avoid exercise for the week before the study
What is involved in the Study?
This study involves one (1) screening visit where you will ride an exercise bike to determine your V02 max and wear a continuous glucose sensor (CGM). About 1 week later, you will return to the University of Minnesota for one (1) full day and one half (1/2) day visit. At the full day visit you will ride an exercise bike and be given either naloxone or a placebo. The following day, we will lower your blood sugar to make you hypoglycemic and ask you about your symptoms. You will return about 8 weeks later to repeat the full day and half day parts of the study.