Cerebral Responses to Insulin-Induced Hypoglycemia
What is the Study about?
This study is looking for participants with type 1 diabetes and impaired awareness of hypoglycemia to determine the rates of blood flow to different parts of the brain in response to low blood sugar. Hypoglycemia is a serious complication of diabetes treatments and having a greater understanding of how the brain adapts to low blood sugar may help us develop better and safer ways to treat diabetes.
Eligibility to participate
You may be eligible to participate in this Study if you:
- Are between the age of 18 – 65
- Weigh less than 300 lbs
- Have type 1 diabetes
- Are unaware of when your blood sugar is low
- Have no metallic substances in your body that cannot be removed
What is involved in the Study?
This study involves one (1) half day visit (about 6 hours) to the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota. Participants will be given an IV infusion of glucose, insulin, and potassium to lower blood sugar while in a magnetic resonance scanner (MRI). Images of the brain will be taken with the MRI and blood will be collected for additional tests.