Cerebral Responses to Insulin-Induced Hypoglycemia

What is the Study about?

The purpose of this study is to better understand the effect of low blood sugar (hypoglycemia) on blood flow to and biochemistry in the brain. Hypoglycemia is a serious complication of diabetes treatments. It has been previously observed that hypoglycemia causes an increase in blood flow to certain parts of the brain, but it has been difficult to determine which parts of the brain specifically have an increase in blood flow. With new technology, it is now possible to determine the rate of blood flow in very small parts of the brain. We expect that people with type 1 diabetes and hypoglycemia unawareness, poorly controlled diabetes, and normal subjects will have different rates of blood flow to different parts of the brain in response to hypoglycemia. Having a greater understanding of how the brain adapts to hypoglycemia may help us develop better ways to treat diabetes more safely.

Eligibility to participate

You may be eligible to participate in this Study if you:

  • Are between the age of 18 – 65
  • Have type 1 diabetes

This study is also accepting healthy participants.
This study is currently recruiting participants.

What is involved in the Study?

Participants with diabetes and healthy participants will be asked to visit the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota 1-3 times for up to 6 hours each time and participate in up to 3 tests in a high field magnetic resonance scanner (MRI).

  • Test 1: Infusion study – an IV infusion of glucose, insulin, and potassium will be given while in the scanner
  • Test 2: Breathing study – you will be asked to hold your breath for a short time while in the scanner
  • Test 3: Non-infusion study – you will be asked to lie still in the scanner for a short time

Principal Investigator

Elizabeth Seaquist, MD

For More Information

Anjali Kumar, PA-C
(612) 624-0470