David Boulware, MD, MPH, CTropMed®

Lois & Richard King Distinguished Associate Professor, Division of Infectious Diseases and International Medicine

David Boulware

Contact Info

Mailing Address:
Division of Infectious Disease and International Medicine
Microbiology Research Facility (MRF) 4-103
689 SE 23rd Ave
Minneapolis, MN 55455

Administrative Assistant Name
Debbie Rootes

Administrative Phone
612-624-1966

Administrative Email
Roote001@umn.edu

Administrative Fax Number
612-301-1292

Lois & Richard King Distinguished Associate Professor, Division of Infectious Diseases and International Medicine


Infectious Disease Physician


Medical School, Indiana University School of Medicine, Indianapolis, IN

Internal Medicine and Pediatrics Residency, University of Minnesota, Minneapolis, MN

Infectious Disease Fellowship, University of Minnesota, Minneapolis, MN

Summary

Dr. Boulware is an infectious disease physician-scientist with formal training in public health, clinical trials, and tropical medicine. As a translational researcher, Dr. Boulware combines his clinical research training with basic science investigations into disease pathogenesis. His primary research interests are in meningitis in resource-limited areas including diagnosis, prevention, treatment, and quality improvement initiatives incorporating cost-effectiveness analyses in order to translate knowledge into improved care. Dr. Boulware and his team’s current research is focused on improving the clinical outcomes of HIV-infected persons with cryptococcal meningitis, the second most common AIDS-defining opportunistic infection in Sub-Saharan Africa and the most common cause of adult meningitis. Why Cryptococcus? During 2016 in Uganda, cryptococcal meningitis accounts for ~70% of adult meningitis. Prevention with targeted cryptococcal antigen screening and preemptive therapy for early disseminated Cryptococcus infection is of great interest. Dr. Boulware has active research collaborations in Uganda, South Africa, Tanzania, and Ethiopia leading a multidisciplinary, international research team.

Awards & Recognition

  • Educational Excellence Award for the Department of Medicine, Univ. of Minnesota, 2011
  • Lois & Richard King Distinguished Associate Professor

Professional Associations

  • DHHS-IDSA Working Group on Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-Exposed and HIV-Infected Children, 2007
  • American Society of Tropical Medicine & Hygiene, CTropMed Examination committee
  • American Society of Tropical Medicine & Hygiene, Scientific Program Committee
  • World Health Organization (WHO) Cryptococcal Guidelines Peer Review committee

Research

Research Summary/Interests

  • Phased Implementation of a Public Health Programme: Cryptococcal Screening and Treatment in South Africa (R01 AI118511)
  • Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis. (UK MRC)
  • Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis (R01 NS086312)
  • Trial for the Optimal Timing of HIV Therapy after Cryptococcal Meningitis (U01 AI089244)
  • Operational Research for Cryptococcal Antigen Screening to improve ART Survival (U01 GH11005)

Research Projects:

  • Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis (R01 NS086312)
  • Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis (UK MRC/DfID/Wellcome Trust Global Health Trials)
  • Phased Implementation of a Public Health Programme: Cryptococcal Screening and Treatment in South Africa. (R01AI118511)
  • Operational Research for Cryptococcal Antigen Screening (ORCAS) of HIV Patients (U01AI125003)
  • Doris Duke International Clinical Research Fellowship program for Medical Students (PI)
  • Infectious Disease Training in Clinical Investigation (T32AI055433)
  • NIH Partnership for Research on Ebola Virus in Liberia (Prevail) Team Member, Prevail II (ZMapp) Trial Protocol writer, Prevail I/II/IV Medical Monitor.

Publications

Out of more than 109 peer-reviewed publications; see full listing on PubMed.

  • Rhein J, Morawski BM, Hullsiek KH, Nabeta HW, Kiggundu R, Tugume L, Musubire AK, Akampurira A, Smith KD, Alhadab A, Williams DA, Abassi M, Bahr NC, Velamakanni SS, Fisher J, Nielsen K, Meya DB, Boulware DR, on behalf of ASTRO-CM Study Team. Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: An open-label dose-ranging study. Lancet Infect Dis. 2016; 16: 809-18. doi: 10.1016/S1473-3099(16)00074-8.
  • Bahr NC, Tugume L, Rajasingham R, Kiggundu R, Williams DA, Morawski B, Alland D, Meya DB, Rhein J, Boulware DR. Improved diagnostic sensitivity for TB meningitis with Xpert MTB/Rif testing of centrifuged CSF: a prospective study. Int J Tuberc Lung Dis. 2015; 19: 1209-15.doi:10.5588/ijtld.15.0253.
  • Boulware DR, Meya DB, Muzoora C, Rolfes MA, Huppler Hullsiek K, Musubire A, Taseera K, Nabeta HW, Schutz C, Williams DA, Rajasingham R, Rhein J, Thienemann F, Lo MW, Nielsen K, Bergemann KL, Kambugu A, Manabe YC, Janoff EN, Bohjanen PR, Meintjes G, COAT Team. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med. 2014; 370; 2487-98. PMC4127879 doi: 10.1056/NEJMoa1312884
  • Rolfes MA, Huppler Hullsiek K, Rhein J, Nabeta HW, Taseera K, Schutz C, Musubire A, Rajasingham R, Williams DA, Thienemann F, Muzoora C, Meintjes G, Meya DB, Boulware DR. The effect of therapeutic lumbar punctures on acute mortality from cryptococcal meningitis. Clin Infect Dis. 2014; 59: 1607-14. doi: 10.1093/cid/ciu596
  • Rajasingham R, Rhein J, Klammer K, Musubire A, Nabeta H, Akampurira A, Mossel EC, Williams DA, Boxrud DJ, Crabtree MB, Miller BR, Rolfes MA, Tengsupakul S, Andama AO, Meya DB, Boulware DR. Epidemiology of Meningitis in an HIV-infected Ugandan Cohort. Am J Trop Med Hyg. 2014; 92(2):274-9. PMC4347329
  • Bahr NC, Rolfes MA, Musubire A, Nabeta H, Williams DA, Rhein J, Kambugu A, Meya DB, Boulware DR. Standardized electrolyte supplementation and fluid management improves survival during amphotericin therapy for cryptococcal meningitis in resource-limited settings. Open Forum Infect Dis 2014: 1: ofu070. doi: 10.1093/ofid/ofu070
  • Boulware DR, Rolfes MA, Rajasingham R, von Hohenberg M, Qin Z, Taseera K, Schutz C, Kwizera R, Butler EK, Meintjes G, Muzoora C, Bischof JC, Meya DB. Multisite validation of cryptococcal antigen lateral flow assay and quantification by laser thermal contrast. Emerg Infect Dis. 2014; 20: 45-53. PMC3884728 doi: 10.3201/eid2001.130906
  • Carlson RD, Rolfes MA, Birkenkamp KE, Nakasujja N, Rajasingham R, Meya DB, Boulware DR. Predictors of neurocognitive outcomes on antiretroviral therapy after cryptococcal meningitis: A prospective cohort study. Metabol Brain Dis.2014; 29: 269-279. PMC4033836 doi: 10.1007/s11011-013-9476-1
  • Durski KN, Kuntz KM, Yasukawa K, Virnig BA, Meya DB, Boulware DR. Cost-effective diagnostic checklists for meningitis in resource limited settings. J Acquir Immune Defic Syndr.2013; 63:e101-108. Doi: 10.1097/QAI.0b013e31828e1e56
  • Rajasingham R, Rolfes MA, Birkenkamp K, Meya DB, Boulware DR. Cryptococcal meningitis treatment strategies in resource-limited settings: a cost-effectiveness analysis. PLoS Med. 2012; 9: e1001316. doi: 10.1371/journal.pmed.1001316
  • Meya DB, Manabe YC, Castelnuovo C, Cook BA, Elbireer AM, Kambugu A, Kamya MR, Bohjanen PR, Boulware DR. Cost-effectiveness of serum cryptococcal antigen screening to prevent deaths among HIV-infected persons with a CD4+ <100 cells/mcL who start HIV therapy in resource-limited settings. Clin Infect Dis. 2010; 51:448-55. PMC2946373

Clinical

Clinics

Delaware Street Clinic (Infectious Disease/HIV Clinic)

Board Certifications

  • Internal Medicine
  • Infectious Diseases
  • International Society of Travel Medicine, Certificate of Knowledge
  • American Society of Tropical Medicine & Hygiene, Certification in Tropical Medicine & Travelers’ Health

Clinical Interests

Central nervous system infections; AIDS-related opportunistic infections; Tropical medicine; Travel medicine; Cost Effectiveness

Hospital Privileges

University of Minnesota Medical Center, Fairview