Zohar Sachs, MD, PhD

Assistant Professor of Medicine, Division of Hematology, Oncology and Transplantation

Zohar Sachs

Contact Info

sachs038@umn.edu

Office Phone 612-626-7055

Mailing Address:
Division of Hematology, Oncology and Transplantation
420 Delaware Street SE
MMC 480
Minneapolis, MN 55455

Administrative Assistant Name
Pam Hansen

Administrative Email
hanse032@umn.edu

Medical School, Tufts University School of Medicine, Boston, MA

Residency, Caritas St. Elizabeth's Medical Center, Brighton, MA

Fellowship, University of Minnesota, Minneapolis, MN

Summary

Dr. Zohar Sachs received her undergraduate degree, a BS in Chemical Engineering, from the Massachusetts Institute of Technology (Cambridge). She then attended the Tufts Medical School Medical Scientist Training Program (Boston), receiving an MD/PhD. Dr. Sachs completed her residency in Internal Medicine at Caritas St. Elizabeth’s Medical Center (Boston). Dr. Sachs conducted her fellowship in Hematology, Oncology and Transplantation at the University of Minnesota. In 2012 she became a member of the faculty.

Dr. Sachs leads a basic and translational research lab focused on identifying the molecular mechanisms of self-renewal in acute myelogenous leukemia.

Research

Research Summary/Interests

Acute myeloid leukemia stem calls
My lab’s goal is to identify molecular mechanisms of leukemia stem cell self-renewal in primary murine and human acute myeloid leukemia (AML). Self-renewal is a feature of leukemia stem cells that allow them to recapitulate leukemia and cause relapse. Since AML cells are highly heterogenous, we specialize in the application of single-cell, high throughput technologies (including mass cytometry/CyTOF and single-cell RNA sequencing) to address these research questions.

My earlier work demonstrated that the activated NRAS oncogene mediates self-renewal in AML and that individual leukemia cells vary significantly in their functional status and ability to self-renew (Sachs et al. Blood 2014). Recently, we defined the gene expression profile of AML self-renewal at the single-cell level and used this data to identify a functionally unique subset of leukemia cells with leukemia-repopulating potential. We are using these approaches to identify effective therapeutic targets for this deadly disease.

Clinical

Specialties

  • Cancer
  • Hematology/Oncology

Clinics

Masonic Cancer Center

Board Certifications

  • Internal Medicine
  • Hematology

Clinical Interests

AML; Myeloid malignancies; Leukemia; Bone marrow diseases; Lymphoma; Myelodysplastic syndrome