Martin Felices, PhD

Assistant Professor of Medicine, Division of Hematology, Oncology and Transplantation

Martin Felices

Contact Info

Mailing Address:
Division of Hematology, Oncology and Transplantation
420 Delaware Street SE
MMC 480
Minneapolis, MN 55455

Administrative Assistant Name
Bickie Pham

Administrative Phone
612-625-8287

Administrative Email
pham0179@umn.edu

PhD, University of Massachusetts Amherst, Amherst, MA

Worcester Polytechnic Institute, Worcester, MA

Summary

Dr. Felices received his Ph.D. in immunology from UMASS Medical School in 2008, where his research focused on innate and adaptive immune subsets. He then pursued an industry postdoctoral fellowship at Novartis Institutes for BioMedical Research, in Cambridge, MA, in the Developmental and Molecular Pathways group where he studied signaling pathways involved in liver injury and tumorogenesis. In 2011 he joined the University of Minnesota as a T32 postdoctoral fellow in the HOT division, focusing his research on NK cell biology, prior to becoming an assistant professor.

Expertise

  • Innate and Adaptive Immunology
  • Cellular Biology
  • Signal Transduction

Awards & Recognition

  • The American Association of Immunologists
  • Society for Natural Immunity

Research

Research Summary/Interests

  • NK cell biology (development, survival, and function)
  • Cancer immunology
  • Signal transduction
  • Immune metabolism

Publications

  • Felices M, Lenvik TR, Ankarlo DE, Foley B, Curtsinger J, Luo X, Blazar BR, Anderson SK, Miller JS. Functional NK Cell Repertoires Are Maintained through IL-2R? and Fas Ligand. J Immunol. 2014 Mar 14
  • Foley B*, Felices M*, Cichocki F, Cooley S, Verneris MR, Miller JS. The biology of NK cells and their receptors affects clinical outcomes after hematopoietic cell transplantation (HCT). Immunol Rev. 2014 Mar;258(1):45-63.
  • Gleason MK, Lenvik TR, McCullar V, Felices M, O'Brien MS, Cooley SA, Verneris MR, Cichocki F, Holman CJ, Panoskaltsis-Mortari A, Niki T, Hirashima M, Blazar BR, Miller JS. Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9. Blood. 2012 Mar 29;119(13):3064-72
  • Cichocki F, Felices M, McCullar V, Presnell SR, Al-Attar A, Lutz CT, Miller JS. Cutting Edge: MicroRNA-181 Promotes Human NK Cell Development by Regulating Notch Signaling. J Immunol. 2011 Dec 15;187(12):6171-5
  • Felices M, Yin C, Kosaka Y, Kang J, Berg LJ. Tec Kinase Itk in ?? T Cells is Pivotal for Controlling IgE Production In Vivo. PNAS. 2009 May;106(20):8308-13
  • Prince AL, Yin CC, Enos ME, Felices M, Berg LJ. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev. 2009 Mar;228(1):115-31.
  • Felices M, Berg LJ. The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival. J. Immunol. 2008 Mar;180(5):3007-18.
  • Lucas J*, Felices M*, Evans JW, Berg LJ. Subtle Defects in Pre-TCR Signaling in the Absence of the Tec Kinase Itk. J. Immunol. 2007 Dec;179:7561-7567
  • Felices M, Falk M, Kosaka Y, Berg LJ. Tec kinases in T cell and mast cell signaling. Adv Immunol. 2007;93:145-84
  • Kosaka Y, Felices M, Berg LJ. Itk and Th2 responses: action but no reaction. Trends Immunol. 2006 Oct;27(10):453-60
  • Felices M, Ankarlo DE, Lenvik TR, Nelson HH, Blazar BR, Verneris MR, Miller JS. Notch Signaling at Later Stages of NK cell Development Enhances KIR Expression and Functional Maturation. J Immunol. 2014 Oct 1;193(7):3344-54
  • Felices M, Lenvik TR, Ankarlo DE, Foley B, Curtsinger J, Luo X, Blazar BR, Anderson SK, Miller JS. Functional NK Cell Repertoires Are Maintained through IL-2R? and Fas Ligand. J Immunol. 2014 Apr 15;192(8):3889-97