Harry Jacob, MD

Professor of Medicine (Emeritus), Division of Hematology, Oncology and Transplantation

Harry Jacob

Contact Info

Mailing Address:
Division of Hematology, Oncology and Transplantation
420 Delaware Street SE
MMC 480
Minneapolis, MN 55455

Administrative Assistant Name
Barbara Powit

Administrative Phone
612-624-5620

Administrative Email
porw0001@umn.edu

Administrative Fax Number
612-625-6919

Professor of Medicine (Emeritus), Division of Hematology, Oncology and Transplantation


Hematologist / Oncologist


Summary

Dr. Jacob was head of the Division of Hematology from 1968 to 1998 when it merged with the Division of Medical Oncology. At that time, he became Professor Emeritus. Following graduation from Reed College in 1954, Dr. Jacob graduated from Harvard Medical School cum laude in 1958. He was a founding chief medical editor of HemOnc Today.
Dr. Jacob continues in active clinical practice and in teaching students, residents and fellows.

Research

Research Summary/Interests

Dr. Jacob’s research interests are in hemolytic anemias, inflammatory mechanisms of vascular damage including atherosclerosis and acute respiratory disease, and autoimmune disorders.

Publications

  • Balla J, Vercellotti GM, Jeney V, Yachie A, Varga Z, Jacob HS, Eaton JW, Balla G. Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment. Antioxid Redox Signal 2007; 9:2119-37. Review.
  • Balla J, Balla G, Jeney V, Kakuk G, Jacob HS, Vercellotti GM. Ferriporphyrins and endothelium: a 2-edged sword-promotion of oxidation and induction of cytoprotectants. Blood. 2006; 95:3442-50.
  • Ujhelyi L, Balla J, Muszbek L, Kakuk G, Belcher J, Jacob HS, Vercellotti GM, Balla G. A microassay to assess the oxidative resistance of low-density lipoproteins. Clin Chem. 1998; 44(8 Pt 1):1762-4.
  • Kovacs A, Weber ML, Burns LJ, Jacob HS, Vercellotti GM. Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells. Am J Pathol. 1996; 149: 1531-9.
  • Jacob HS. Vascular shear-forces and atherogenesis: Roles of shear-provoked endothelial viral infection and heme iron accumulation. Perspectives in Biology and Medicine 1994; 38: 114-124.
  • Paller MS, Jacob HS. Cytochrome P-450 mediates tissue damaging hydroxyl radical formation during reoxygenation of the kidney. PNAS 1994; 91: 7002-7006.
  • Cermak J, Balla J, Jacob HS, et al . Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: Possible role in chemotherapy efficacy. Cancer Research 1993; 53: 5308-5313.
  • Balla G, Jacob HS, Balla J et al . Ferritin: A cytoprotective antioxidant strategem of endothelium. J Biol Chem 1992; 267: 18148-18153.
  • Nath KA, Balla G, Balla J et al . Induction of heme oxygenase is a rapid, protective response in the crush syndrome. J Clin Invest 1992; 90: 267-270.

Clinical

Specialties

  • Cancer Care

Board Certifications

  • Hematology / Oncology