Shuxian Hu, MD

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine

Shuxian Hu

Contact Info

Mailing Address:
1-137 Microbiology Research Facility
689 23rd Ave SE
Minneapolis, Minnesota 55455-1507
UM Delivery Code: 2821A

Lab Address:
1-137 Microbiology Research Facility

Administrative Assistant Name
IDIM

Administrative Phone
612-624-1966

Administrative Email
IDIMDivision@umn.edu

Administrative Fax Number
612-301-1292

Medical School, Beijing Medical University, Beijing, China

Summary

Dr. Shuxian Hu received her medical degree from Beijing Medical University and completed her pediatric and neurology training at the Beijing Medical University first hospital. After completing a fellowship in the Neuroscience Program at the University of Minnesota, she joined the Neuroimmunology Research Laboratory at the Minneapolis Medical Research Foundation. In 2005, she joined the faculty in the Department of Medicine at the University of Minnesota.

Professional Associations

  • International Society for NeuroVirology/ISN
  • Society on NeuroImmune Pharmacology/SNIP

Research

Research Summary/Interests

During the past 27 years, Dr. Hu’s major research interest has been in the area of immune-mediated neuropathogenesis and neurodegenerative diseases, in particular, as related to viral diseases of the brain. A major focus of this research has been on glial cell (microglia and astrocytes) activation and cytokines/chemokines produced by these cells. Dr. Hu is currently (2017) investigating T-cell: glial cell interactions as well as their role in creating and amplifying central nervous system inflammation during CNS virus infection.

Publications

  • Prasad S., Hu S., Sheng WS., Chauhan P., Singh A., Lokensgard J. R. The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis. J Neuroinflammation. 2017;14(1):82
    Chauhan P., Hu S., Sheng WS., Prasad S., Lokensgard J.R. Modulation of Microglial Cell Fcr Receptor Expression Following Viral Brain Infection. Sci Rep. 2017;7:418891.
  • Lokensgard JR, Mutnal MB, Prasad S, Sheng WS, Hu S. Glial activation, ecruitment, and survival of B-lineage cells during MCMV brain infection. Joyrnal of Neuroinflammation. 2016:20;13(1):14
  • Prasad S, Hu S, Sheng WS, Singh A, Lokensgard JR. Tregs Modulate Lymphocy- te Proiferation, Activation, and Resident-Memory T –Cell Accumulation within the Brain during MCMV Infection. Plos One. 2015;10(12):e0145457
  • Lokensgard JR, Schachtele SJ, Mutnal MB, Sheng WS, Prasad S, Hu S. Chronic reactive gliosis following requlatory T cell depletion during acute MCMV encephalitis. Glia. 2015;63(11):1982-1996
  • Schachtele SJ, Hu S, Sheng WS, Mutnal MB, Lokensgard JR. Glial cells suppress postencephalitic CD8+ T lymphocytes through PD-L1. Glia. 2014;62(10):1582-9
  • Hu S, Rotschafer JH, Lokensgard JR, Cheeran MCJ. Activated CD8+ T lymphocytes inhibit neural stem/progenitor cell proliferation. Plos One. 2014;9(8):e105219
  • Mutnal MB, Hu S, Schachtele SJ, Lokensgard JR. Infiltrating regulatory B cells control neuroinflammation following viral brain infection.2014 Dec 15;193(12):6070-80
  • Hu S, Sheng WS, Schachtele SJ, Lokensgard JR. Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflamnatory cytokine production by murine microglia. J Neuroinflammation. 2011; 26;8:123
  • Hu S, Sheng WS, Lokensgard JR, Peterson Pk, Rock RB. Preferential sensitivity of human dopaminergic neurons to gp120-ind oxidative damage. Journal of NeuroVirology. 2009;15(5-6);401-410
  • Armien AG, Hu S, Little MR, Robinson NA, Lokensgard JR, Low W, Cheeran MCJ. Chronic cortical and Subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis. Brain Pathology. 2010; 20(4):738-750