Irina St. Louis, MD, PhD

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine

Irina St. Louis

Contact Info

Mailing Address:
Division of Infectious Diseases and International Medicine
420 Delaware Street SE
MMC 250
Minneapolis, MN 55455

Lab Address:
Mayo 820-2
420 Delware STreet SE
Minneapolis, MN 55455

Administrative Assistant Name
IDIM

Administrative Phone
612-624-1966

Administrative Email
IDIMDivision@umn.edu

Administrative Fax Number
612-301-1292

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine


Infectious Diseases Specialist


Medical School, Ural State Medical Academy, Russia

Residency, Medical Academy for Postgraduate Education, Moscow, Russia

Fellowship, University of Minnesota, Minneapolis, MN

PhD, Ural State Medical Academy, Russia

Summary

Irina St. Louis earned her M.D. and Ph.D. degrees from Ural State Medical Academy, Yekaterinburg, Russia. She completed her residency in lab pathology at Russian Medical Academy for Postgraduate Education, Moscow. Dr. St. Louis joined the Department of Microbiology, at University of Minnesota, as a postdoctoral trainee, followed by fellowships at the University of Minnesota Supercomputing Institute and Lymphoma Research Foundation.

Dr. St. Louis is appointed as an Assistant Professor at the Department of Medicine. Her current clinical project focuses on the identification of molecular biomarkers for immune restoration diseases. The basic research in her Laboratory is centered on the area of post-transcriptional gene expression regulation, specifically through messenger RNA degradation.

Expertise

  • Cellular and molecular biology
  • genomics
  • transcriptomics
  • proteomics

Research

Research Summary/Interests

Dr. St. Louis conducts discovery research in several key areas including infectious diseases, immunology, and oncology. By integrating specific areas of expertise - genomics, proteomics, ribonomics, and bioinformatics - Irina’s group is studying normal and pathological conditions at the molecular, cellular, and organismal levels.

The basic research in Dr. St. Louis’ laboratory is centered on post-transcriptional gene expression regulation, specifically, through messenger RNA turnover.

Her translational research focuses on immune restoration disorders (IRD). Dr. St. Louis is engaged in a number of clinical studies, within the Global Health & International Medicine Program. These studies involve the stratification of AIDS patients, for optimal treatment regimens. The studies also include searches for biomarkers of immune reconstitution inflammatory syndrome (IRIS). Additionally, Dr. St. Louis’ lab collaborates with the Division of Hematology Oncology and Transplantation, on virus-specific immune reconstitution, after various hematopoietic cell transplantation regimens. This collaborative research aims to define the parameters and conditions for favorable post-transplant immune restoration and functional recovery in adult patients.

Publications

  • Irina Vlasova-St. Louis, Christina C Chang, Samar Shahid, Martyn A French and Paul R Bohjanen. Transcriptomic biomarkers of paradoxical Cryptococcosis-associated immune reconstitution inflammatory syndrome. J Open Forum Infect Dis. 2018, July, in print.
  • Guo L., Vlasova-St Louis I, Bohjanen PR. Post-transcriptional regulation of cytokine expression and signaling. Current trends in immunology. June 2018 June, in print.
  • Irina Vlasova-St. Louis and Calandra Sagarsky. Mammalian Cis-Acting RNA Sequence Elements. Textbook chapter 3, Book: Mammalian gene expression and regulation. InTech, 2018 Feb 21. DOI: 10.5772/intechopen.72124.
  • Guo L., Vlasova-St Louis I, Bohjanen PR. Viral manipulation of host mRNA decay, Future Virology, 2018 Mar;13(3):211-223. PMID: 29750084.
  • Liang Guo, Suresh D. Sharma, Jose Debes, Daniel Beisang, Bernd Rattenbacher, Irina Vlasova-St. Louis, Darin L. Wiesner, Cavan Reilly, Craig E. Cameron, Paul R. Bohjanen. The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts. NAR, 2018 Jan;46(5)2537–2547. PMID: 29385522.
  • Vlasova-St Louis I, Bohjanen PR. Post-transcriptional regulation of cytokine and growth factor signaling in cancer. Cytokine Growth Factor Rev. 2017 Feb;33:83-93. PMID: 27956133
  • Vlasova-St. Louis and P.R. Bohjanen. Feedback Regulation of Kinase Signaling Pathways by AREs and GREs. Cells. 2016 5(1). PMID: 26821046.
  • Irina Vlasova-St. Louis and Paul R. Bohjanen. Post-transcriptional Regulation of Cytokine Signaling During Inflammatory Responses. Book, Springer. Post-transcriptional Mechanisms in Endocrine Regulation. 2016, chapter 3, p.55-70. DOI 10.1007/978-3-319-25124-0
  •  Bohjanen PR, Moua ML, Guo L, Taye A, Vlasova-St Louis IA. Altered CELF1 binding to target transcripts in malignant T cells. RNA. 2015 Oct;21(10):1757-69. PMID: 26249002
  • Vlasova-St Louis I, Bohjanen PR. Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements. J Interferon Cytokine Res. 2014 Apr;34(4):233-41. PMID: 24697201
  • Vlasova-St Louis I, Dickson AM, Bohjanen PR, Wilusz CJ. CELFish ways to modulate mRNA decay. Biochim Biophys Acta. 2013, Jan 15. PMID: 23328451
  • Beisang D, Bohjanen PR and Vlasova-St Louis IA. CELF1 is a multifunctional regulator of posttranscriptional networks. Binding Protein, Book. InTech publisher. 2012, Chapter 8. pp. 112-240. DOI: 10.5772/2897
  • Beisang D, Rattenbacher B, Vlasova-St Louis IA, Bohjanen PR. Regulation of CUG-binding protein 1 (CUGBP1) binding to target transcripts upon T cell activation. J Biol Chem. 2012, Jan 6;287(2):950-60. PMID: 22117072
  • Vlasova-St. Louis IA, Bohjanen PR. Coordinate regulation of mRNA decay networks by GU-rich elements and CELF1. Current Opinion in Genetics & Development. 2011, Aug;21(4):444-51. PMID: 21497082
  • Anason S. Halees, Edward Hitti, Maher Al-Saif, Irina A. Vlasova-St. Louis, Daniel J. Beisang, Paul R. Bohjanen and Khalid S.A. Khabar. Global assessment of GU-rich regulatory content and function of the human transcriptome. RNA Biology. 2011, Jul 1;8(4): 681-691. PMID:21691152
  • Rattenbacher B, Beisang D, Wiesner DL, Jeschke JC, von Hohenberg M, Vlasova-St. Louis IA and Bohjanen PR. Analysis of CUGBP1 targets identifies GU-repeat sequences that mediate rapid mRNA decay. Mol Cell Biol. 2010, Jun 14. Vol.30, No.16. PMID: 20547756
  • Rachel L. Ogilvie, Julius R. SternJohn, Irina A. Vlasova-St. Louis, Bernd Rattenbacher and Paul R. Bohjanen. Tristetraprolin Mediates Interferon-gamma mRNA Decay. J Biol. Chem. 2009, Apr 24;284(17):11216-11223. PMID: 19258311
  • Vlasova I.A., Bohjanen P.R. Posttranscriptional regulation of gene networks by GU-rich elements and CELF proteins. Review. RNA Biology. 2008, Oct 23;5(4). PMID: 18971639
  • Irina A. Vlasova, Nuzha M. Tahoe, Danhua Fan, Ola Larsson, Bernd Rattenbacher, Julius R. SternJohn, Cavan S. Reilly, Peter B. Bitterman, and Paul R. Bohjanen. Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1. Molecular Cell. 2008, Feb 1;29(2):263-70. PMID: 18243120
  • Graham RR, Kyogoku C, Sigurdsson S, Vlasova IA, Davies LR, Baechler EC, et al. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci USA 2007, 104: 6758-63. PMID:17412832
  • Irina A Vlasova, Jennifer McNabb, Arvind Raghavan, Cavan Reilly, Darlisha Williams and Paul R Bohjanen. Coordinate stabilization of growth-regulatory transcripts in T cell malignancies. Genomics. 2005, Aug;86(2):159-71. PMID: 15979272
  • R.L. Ogilvie, M. Abelson, H. Hau, I.A. Vlasova, P. Blackshear, and P.R. Bohjanen. Tristetraprolin Down-Regulates Interleukin-2 Gene Expression through AU-rich Element-Mediated mRNA Decay. J. of Immunology. 2005, Jan 15;174(2):953-61. PMID: 15634918
  • Raghavan, M. Dhalla, T. Bakheet, R. Ogilvie, I. Vlasova, K. Khabar, D. Williams, and P. R. Bohjanen. Patterns of Coordinate Down-regulation of ARE-containing Transcripts following Immune Cell Activation. Genomics. 2004, Dec;84(6):1002-13. PMID: 15533717

Teaching

Academic Interests and Focus

Foundation of Critical Thinking in Medicine course for medical students

Clinical

Clinical Interests

Molecular medicine; Lab pathology; microbiology