Geoffrey Hart, PhD

Assistant Professor, Division of Infectious Diseases and International Medicine

Geoffrey Hart

Contact Info

hart0792@umn.edu

Office Phone 612-626-3093

Mailing Address:
Microbiology Research Facility
689 23rd Ave. SE
Room 2-103
DC 2821A
Minneapolis, MN 55455

Lab Address:
Microbiology Research Facility
689 23rd Ave. SE
Room 2-133
DC 2821A
Minneapolis, MN 55455

Administrative Assistant Name
Tom Zuhars

Administrative Phone
612-624-9996

Administrative Email
zuhar001@umn.edu

Administrative Fax Number
612-625-4410

Malaria Research Program, NIAID, NIH

PhD, Microbiology, Immunology, and Cancer Biology (MICaB), University of Minnesota, Minneapolis, MN

BS, Bates College, Lewiston, Maine


    Summary

    Dr. Hart performed his dissertation research in the Center for Immunology at the University of Minnesota. Postdoctoral work at the NIH has focused on malaria research. His primary interest is centered on innate immunity, particularly NK cells, in malaria. Using a basic immunology approach, he collaborates with on-going studies in malaria endemic regions of Africa to try to understand protective and pathological mechanisms of this deadly disease.

    Expertise

    • Human innate Immunology
    • Natural Killer cells
    • Infectious Disease
    • Malaria

    Research

    Research Summary/Interests

    • Basic human immunology
    • Malaria immunity and pathogenesis
    • Antibody mediated immunity
    • Innate inflammation regulation

    Human immunology of malaria
    There is no approved vaccine for malaria, and there are still many fundamental unanswered questions for malaria immunity. The Hart lab believes many of these unanswered questions lie where innate immunity intersects with the adaptive immune system. Using a basic immunology approach, they collaborate with on-going studies in malaria endemic regions of Africa. Current malaria projects center around understanding the mechanism of antibody mediated immunity and innate regulatory mechanisms (or lack thereof) in pathological immune responses. We use human subject samples primarily for our studies, and we are also developing novel mouse models to better understand in vivo dynamics where needed.

    Dr. Hart is a new Primary Investigator in the MICaB program and is excited to train and mentor the next generation of MICaB graduate students. Rotation spots are currently available for the 2017 incoming class. Please apply via email (hart0792@umn.edu).

    Publications

    • Hart, G.T., Akkaya, M., Chida, A.S., Wei, C., Jenks, S.A., Tipton, C., He, C., Wendel, B.S., Skinner, J., Arora, G., Kayentao, K., Ongoiba, A., Doumbo, O., Traore, B., Narum, D.L., Jiang, N., Crompton, P.D., Sanz, I., and Pierce S.K. 2016 The Regulation of Inherently Autoreactive VH4-34+ Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa. Journal of Immunology 197 (10).
    • Gordon E.B., Hart G.T. (co-first), Tran T.M.,Waisberg M., Akkaya M., Kim, A.S., Hamilton, S.E., Pena M., Yazew T., Qi C.F., Lee, C., Lo, Y., Miller L.H., Powell, J.D., Pierce S.K. 2015. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. PNAS (ePub Oct. 5th, 2015)
    • Gordon E.B., Hart G.T. (co-first), Tran T.M., Waisberg M., Akkaya M., Skinner J., Zinöcker S., Pena M., Yazew T., Qi C.F., Miller L.H., Pierce S.K. 2015 Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria. mBio 6:e00725.
    • Crompton, P.D., Moebius, J., Portugal, S., Waisberg, M., Hart, G., Garver, L.S., Miller, L.H., Barillas-Mury, C., Pierce, S.K. 2014 Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annual Reviews in Immunology 32:157-87.
    • Hart, G. T., Peery, S. L., Hamilton, S. E., Jameson, S. C. 2012. Cutting Edge: Kruppel-like Factor 2 Is Required for Phenotypic Maintenance but Not Development of B1 B Cells. Journal of Immunology 189: 3293-7.
    • Hart, G. T., Hogquist, K. A., Jameson, S. C. 2012. KLF transcription factors in lymphocytes. Journal of Immunology 189: 521-6.
    • Hart, G. T., Wang, X., Hogquist, K. A., and Jameson S. C.,2011. KLF2 regulates B cell reactivity, subset differentiation, and trafficking molecule expression. PNAS 108:716-21.
    • Takada, K., Wang, X., Hart, G. T., Odumade, O. A., Weinreich, M. A., Hogquist, K. A., and Jameson, S. C. 2011. KLF2 is required for trafficking but not quiescence in post-activated T cells. Journal of Immunology 186:775-83.

    Teaching

    Teaching Areas

    • Immunology
    • Cellular and Molecular Biology

    Clinical

    Clinical Interests

    Vaccine development; Immunotherapy