David Perlman, MD

Assistant Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine

David Perlman

Contact Info

Mailing Address:
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine
420 Delaware Street SE
MMC 276 (Pulmonary)
MMC 434 (Allergy)
Minneapolis, MN 55455

Administrative Assistant Name

Administrative Phone

Administrative Email

Administrative Fax Number

Assistant Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine

Director of Interstitial Lung Disease Program, Department of Medicine

Pulmonologist and Critical Care Physician (also at Southdale MICU and Maple Grove Clinic)

Medical School, University of Minnesota, Minneapolis, MN

Internal Medicine Residency, Hennepin County Medical Center, Minneapolis, MN

Pulmonary/Critical Care Fellowship, University of Minnesota, Minneapolis, MN


Dr. Perlman received his B.A. in biology from Carleton College in Northfield, Minnesota in 1989. After college he worked as a research assistant in the lab of Dr. Radovan Zak at the University of Chicago, working mainly on projects relating to the recovery from injury of skeletal and cardiac muscle. He subsequently returned to Minnesota to attend medical school and received his M.D. from the University of Minnesota in 1996. After completing his residency in Internal Medicine at Hennepin County Medical Center, he entered the Pulmonary and Critical Care Medicine Fellowship program at the U of MN.



  • Stewart AF, Camoretti-Mercado B, Perlman D, Gupta M, Jakovic S, Zak R. Structural and phylogenetic analysis of the chicken ventricular myosin heavy chain rod. J Mol Evol 1991; 33(4):357-66
  • Perlman, DM. Enhancing Medical Care at the End of Life. Fellow Reporter. Vol. 7, No. 5, July 2002
  • Li S, Takasu T, Perlman DM, Peterson MS, Burrichter D, Avdulov S, Bitterman PB, Polunovsky VA. Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release. J Biol Chem, 2003;278:3015-22.
  • Li S, Perlman DM, Peterson MS, Burrichter D, Avdulov S, Polunovsky VA, Bitterman PB. Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis. J Biol Chem, 2004;279:21312-7 .
  • Avdulov S, Li S, Michalek V, Burrichter D, Peterson M, Perlman DM, Manivel JC, Sonenberg N, Yee D, Bitterman PB, Polunovsky VA. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell, 2004; 5: 553-563.
  • Larsson O, Perlman DM, Fan D, Reilly CS, Peterson M, Dahlgren C, Liang Z, Li S, Polunovsky VA, Wahlestedt C, Bitterman PB. Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure. Nucleic Acids Res. 2006; 34(16): 4375-86.
  • Xia H, Diebold D, Nho RS, Perlman D, Kahm J, Kleidon J, Avdulor A, Peterson M, Bitterman P, Henke CA. Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients' idiopathic pulmonary fibrosis. 2008, J Exp Med. 2008; 205(7):1659-72. PMCID: PMC2442643



Center for Lung Science and Health;Transplant Center

Board Certifications

  • Internal Medicine
  • Pulmonary, Critical Care

Clinical Interests

General pulmonary medicine; Critical care medicine; Pulmonary fibrosis; Environmentally-associated lung disease