Cyprian Weaver, PhD, MS, BA

Associate Professor of Medicine, Cardiology

Cyprian Weaver

Contact Info

Mailing Address:
Cancer & Cardiovascular Research Building
2231 6th St. SE
CCRB 4-144

Administrative Assistant Name
Jane Hutchins-Peterson

Administrative Phone
612-626-2505

Administrative Email
jhutchin@umn.edu

Administrative Fax Number
612-301-8298

Associate Professor of Medicine, Cardiology


PhD, Neuroendocrinology, University of Minnesota, Minneapolis, MN

PhD, Human Biology, University of Colorado, Boulder, CO

MS, Neuroanatomy, University of Minnesota, Minneapolis, MN

MS, Forensic/Physical Anthropology, University of Colorado, Boulder, CO

MA, Theology (Systematics), Saint John’s University, Collegeville, MN

BA, Philosophy/Natural Science, Saint John’s University, Collegeville, MN

Summary

My interest has traditionally been the hormonal regulation of regeneration as evidence in the modulating hormonal crosstalk with various transcription factors involved in tissue maintenance and regeneration. Included among these are the in vivo and in vitro effects of insulin, thyroid hormone, prolactin and their agonists and antagonists on neonatal cardiomyocytes. The focus and emphasis has been on assessing these agents in prolonging the early neonatal potential of cardiomyocyte proliferative potential and how this might be implemented in the adult milieu of postmitotic cardiomyocytes that normally non-regenerative upon cellular loss or injury.

Awards & Recognition

  • Presidential Citation and Ministry of Education Award for Educational 2007
  • Excellence and Service to the Republic of China, awarded by President Chen Shui-Bian 
  • Outstanding Research Award, Medical College, Fu Jen University, 2004 Hsinchuang, Taipei Hsien, Taiwan, Republic of China 
  • Outstanding Teaching Award, Medical College, Fu Jen University, 1999 Hsinchuang, Taipei Hsien, Taiwan, Republic of China 
  • Outstanding Teaching Award, Medical College, Fu Jen University, 1996 Hsinchuang, Taipei Hsien, Taiwan, Republic of China 

Research

Research Summary/Interests

My interest has traditionally been the hormonal regulation of regeneration as evidence in the modulating hormonal crosstalk with various transcription factors involved in tissue maintenance and regeneration. Included among these are the in vivo and in vitro effects of insulin, thyroid hormone, prolactin and their agonists and antagonists on neonatal cardiomyocytes. The focus and emphasis has been on assessing these agents in prolonging the early neonatal potential of cardiomyocyte proliferation and how this might be implemented in adult postmitotic cardiomyocytes that normally do not regenerate with loss or injury.

Publications

  1. Singh BN, Kren S, Gong W, Weaver CV, Bowlin K, Braulin E. Garry MG, Koyano-Nakagawa N, Garry DJ. 2015. Hedgehog signaling modulates postnatal cardiomyocyte proliferation and regneration in vivo. Genes 6: 417-435.
  2. Singh BN, Weaver CV, Koyano-Nakagawa N, Garry JP. 2015. Visualizing vascular structure in the adult newt (Notophthalmus viridescens) heart. Journal of Medical Devices, 9: 020917.
  3. Weaver CV, Turner N, Hall J. 2012. Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: Immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain. J. Chemical Neuro, 45:1-17. Epub 2012 Jul 13. PMID 22796301 PMCID PMC3455442
  4. Singh BN, Doyle MJ, Weaver CV, Koyano-Nakagawa N, Garry DJ. 2012. Hedgehog and Wnt coordinate signaling in myogenic progenitors and regulate limb regeneration. Developmental Biology, 371(1):23-34. Epub 2012 Aug 10. PMID 22902898 PMCID PMC3987681
  5. Cotsapas C, Prokunina-Olsson L, Welch C, Saxena R, Weaver CV, Usher N, Guiducci C, Bonakdar S, Turner N, LaCroix B, Hall JL. 2010. Expression analysis of loci associated with type 2 diabetes in human tissues. Diabetologia, 53(11):2334-9. Epub 2010 Aug 12. 03/05/2015
  6. Singh BN, Koyano-Nakagawa N, Garry JP, Weaver CV. 2010. Heart of newt: A recipe for regeneration. Journal of Cardiovascular Translational Research. 3(4):397-409. Epub 2010 Jun 16. PMID 20559775
  7. Weaver CV and Garry DJ. 2008. Regenerative biology: A historical perspective and modern applications. Regenerative Medicine, 3(1)63-82. PMID 18154463
  8. Weaver CV and Liu SP. 2008. Differentially expressed pro- and anti-apoptotic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2 and Bcl-w in lung epithelia. Experimental and Toxicologic Pathology 59:265-272. Epub 2008 Feb 21. PMID 18093815
  9. Weaver CV, Liu SP, Lu JS, Lin BS. 2007. The effects of benzene exposure on apoptosis in epithelial lung cells: Localization by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) and the immunocytochemical localization of apoptosis-related gene products. Cell Biology and Toxicology, 23(3):201-220. Epub 2006 Dec 14. PMID 17171516
  10. Yang FL, Chen YS, Weaver CV. 2002. Toxic levels of selenium induces hepatic injury and biliary ductile apoptosis in rats. FASEB J, 16(5):730.20.

Teaching

Academic Interests and Focus

Medical Histology, History of Medicine and Cardiology

Teaching Areas

  • Histology
  • Histopathology
  • Male reproductive system

Courses

Medical Histology, INMD 6821