Craig Henke, MD

Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine

Craig Henke

Contact Info

Mailing Address:
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine
420 Delaware Street SE
MMC 276 (Pulmonary
MMC 434 (Allergy)
Minneapolis, MN 55455

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Administrative Phone

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Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine

Pulmonologist and Critical Care Physician

Medical School, University of Minnesota, Minneapolis, MN

Residency, University of Minnesota, Minneapolis, MN

Fellowship, University of Minnesota, Minneapolis, MN


Dr. Henke graduated from medical school at the University of Minnesota in 1983. He completed residency training in Internal Medicine in 1986 and fellowship sub-specialty training in Pulmonary and Critical Care Medicine in1989, both at the University of Minnesota. Clinical activities and interests include: subspecialty pulmonary clinic focusing on interstitial lung diseases and attending on Pulmonary Consults and in the Medical Intensive Care Unit. Dr. Henke’s research program seeks to understand the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF) at the basic science level. His research program focuses on delineating the phenotype of disease-mediating IPF fibroblasts. Recent discoveries include identification of pathological progenitor cells as a cell-of-origin for IPF fibroblasts. The research program is currently focusing on elucidating epigenetic processes responsible for reprogramming IPF progenitor cells that facilitate pathologic differentiation and acquisition of the IPF fibroblast phenotype. Dr. Henke’s research in IPF is supported by a NIH/NHLBI Program Project Grant and a NIH/NHLBI R01 Grant.

Professional Associations

  • National Research Service Award (1989-1992)
  • 1997 American Heart Association Grant-In-Aid Research Award (1997)
  • American Lung Association Career Investigator Award (2000)
  • American Heart Association Grant-In-Aid Research Award (2002-2005)
  • Member American Journal of Physiology – Lung Cellular and Molecular Physiology Editorial Board (2011-)



  • Henke C, Fiegel V, Peterson M, Wick M, Knighton D, McCarthy J, Bitterman P. Mechanisms of intraalveolar granulation following acute lung injury: Identification and partical characterization of angiogenesis bioactivity in the lower respiratory tract after lung injury. J Clin Invest. 1991; 88:1386-1395.
  • Henke CA, Marinelli WA, Jessurun J, Fox J, Harms D, Peterson M, Chiang L, Doran P. Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury. Am J Pathol 1993; 143:1189-1199.
  • Henke CA, Roongta U, Mickelson DJ, Knutson JR, McCarthy JB. CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix. J Clin Invest 1996; 97:2541-2552.
  • Svee K, White J, Valliant P, Jessurun J, Polunovsky V, Roongta U, Krumwiede M, Johmson D, Henke C. Acute lung injury fibroblast migration and invasion into a fibrin matrix is mediated by CD44. J Clin Invest 1996; 98:1713-1727.
  • Henke C, Bitterman P, Roongta U, Polunovsky V. Induction of fibroblast apoptosis by anti-CD44 antibody: implications for the treatment of fibroproliferative lung disease. Am J Pathol 1996; 149:1639-1650.



  • Pulmonary fibrosis
  • Interstitial lung disease
  • Lung transplantation


Center for Lung Science and Health;Transplant Center

Board Certifications

  • Critical Care Medicine
  • Pulmonary Medicine
  • Internal Medicine

Clinical Interests

Pulmonary fibrosis; Interstitial lung disease; Lung transplantation