Alessandro Magli, PhD, MS, BS

Assistant Professor of Medicine, Cardiovascular Division

Alessandro Magli

Contact Info

Mailing Address:
Cancer and Cardiovascular Research Building
2231 6th St SE
4-130

Lab Address:
Cancer and Cardiovascular Research Building
2231 6th St SE
4-240

Assistant Professor of Medicine, Cardiovascular Division


PhD, Molecular and Regenerative Medicine/Department of Biochemistry, University of Modena and Reggio Emilia, Italy

MS, Medical Biotechnology, University of Modena and Reggio Emilia, Italy

BS, Biotechnology, University of Modena and Reggio Emilia, Italy

Summary

During my undergraduate and graduate studies, I became interested in the mechanisms regulating skeletal myogenic differentiation with a particular focus on the impact of post-translational modifications on the transcriptional activity of MEF2 proteins. Following this initial training, as post-doc I decided to take advantage of the ES cell differentiation system to investigate how transcription factors regulate mesoderm specification during development. In particular, these studies led me to investigate the Pax3/7-dependent epigenetic mechanisms regulating both embryonic myogenic progenitors and adult muscle stem cells. Understanding the molecular regulation of these progenitors will be instrumental for the generation of improved cell-based therapies for muscle diseases and for the development of novel animal model to study muscle function.

Awards & Recognition

  • 2015 Awardee. Minnesota Regenerative Medicine Educational Grant
  • 2010 Travel Award. FASEB Summer Research Conferences
  • 2010 Finalist Visscher Symposium – University of Minnesota

Research

Publications

  • Baik J, Magli A, Tahara N, Swanson SA, Koyano-Nakagawa N, Borges L, Stewart R, Garry D, Kawakami Y, Thomson JA and Perlingeiro RCR (2016) Endoglin Integrates BMP and Wnt Signaling to Induce Hematopoiesis through JDP2. Nature Communications. Oct 7;7:13101.
  • Magli A, Incitti T, Perlingeiro RCR (2016) Myogenic Progenitors from Mouse Pluripotent Stem Cells for Muscle Regeneration. Methods Mol Biol. 2016;1460:191-208.
  • Carrió E, Magli A, Muñoz M, Peinado MA, Perlingeiro RCR and Suelves M (2016) Muscle cell identity requires lineage-specific DNA demethylation. BMC Biology. Apr 13;14:30.
  • Magli A, Schnettler E, Swanson SA, Borges L, Hoffman K, Stewart R, Thomson JA, Keirstead SA, Perlingeiro RC (2014) Pax3 and Tbx5 specify whether PDGFR?+ cells assume skeletal or cardiac muscle fate in differentiating embryonic stem cells. Stem Cells. 32(8):2072-83.