Rupendra Shrestha, MD, MBBS

Assistant Professor of Medicine, Division of Diabetes, Endocrinology and Metabolism

Rupendra Shrestha

Contact Info

Mailing Address:
420 Delaware Street SE
MMC 101
Minneapolis, MN 55455

Administrative Assistant Name
Sommer Wappel

Administrative Phone

Administrative Email

Assistant Professor of Medicine, Division of Diabetes, Endocrinology and Metabolism

Medical School, Manipal College of Medical Sciences, Nepal

Internal Medicine Residency, Danbury Hospital, Danbury, CT

Endocrinology Fellowship, University of Minnesota, Minneapolis, MN


Dr. Rupendra T. Shrestha is Asst. Professor of Medicine at the Division of Diabetes, Endocrinology and Metabolism at the University of Minnesota, focusing clinical care in Thyroid and General Endocrinology. He completed his residency in Danbury Hospital, CT and did research at Beth Israel Deaconess Medical Center in Boston. He completed his fellowship in 2016 from University of Minnesota.

He is currently involved in several thyroid related research at the University of Minnesota. He is the Principal Investigator in Correlation between histological diagnosis and mutational testing of Thyroid Nodules. Dr. Shrestha is currently performing research in areas of improving diagnostic accuracy of thyroid FNA with use of molecular markers and various aspects of thyroid FNA.


Thyroid, Diabetes and Endocrinology

Awards & Recognition

  • Best Poster Award, Danbury Hospital, 2008
  • Physician Collaborator for Excellence in Physician collaboration with support team at Beth Israel Deaconess Medical Center, Milton MA 2013
  • Early Career Award, Endocrine Society 2016

Professional Associations

  • Endocrine Society 2013- Present. Reviewer for abstracts for annual meetings 2015
  • AACE 2014 – Present; ATA 2015 –Present


Research Summary/Interests

Thyroid Nodules

Research Funding Grants

Duration of action and peak effect of high dose U-500 regular insulin in severely insulin resistant subjects with Type 2 DM. IRB: NCT02148250 Funded by Eli Lilly. PI Dr. Elizabeth Seaquist. Role: Coinvestigator.



  • Multiple Mutations Detected Preoperatively May Predict Aggressive Behavior in Papillary Thyroid Cancer and Guide Management - A Case Report. Shrestha, RT, Karunamurthy A, Amin K, Nikiforov YE, Caramori ML. September 2015. Thyroid.
  • Cytologic Subclassification of Atypia of Undetermined Significance May Predict Thyroid Nodules More Likely to be Malignant at Surgery. Accepted Diagnostic Cytopathology 2/2016. Shrestha RT, Hennessey JV


  • Neuropsychiatric Manifestations of Thyroid disease, Feldman AZ, Shrestha RT, Hennessey JV Published 10/2013 Endocrinology and Metabolism Clinic of North America. Sep;42(3):453-76. doi: 10.1016/j.ecl.2013.05.005


  • Acute, Subacute and Reidel’s Thyroiditis. Currently being updated as online book Chapter in Thyroid Disease Manager Shrestha RT, Hennessey JV


  • Correlation between histological diagnosis and mutational testing of Thyroid Nodules - A Two Year Institutional Experience. Manuscript submitted to Thyroid Journal Jan 2016.
  • Axitinib Induced Hyperthyroidism – A case report and literature review. In preparation for submission to Thyroid


Academic Interests and Focus

Grand Rounds: Duodenal Gastrinoma 2009 at Danbury Hospital, CT Morbidity and Mortality presentation: Acute Bacterial Pneumonia 2010 Danbury Hospital. Management of myxedema coma 45 minute group discussion session for residents VA medical center Minneapolis 2015. Small Group Discussion session for second year medical students at University of Minnesota Jan-Feb 2016


Clinical Interests

Diabetes and Endocrinology

Hospital Privileges

University of Minnesota Medical Center, Fairview