Mandy Liu, PhD

Assistant Professor of Medicine, Cardiovascular Division

Mandy Liu

Contact Info

Mailing Address:
CCRB
2231 6th Street SE
MMC: 2812
Minneapolis, MN 55455

Administrative Assistant Name
Jane Hutchins-Peterson

Administrative Phone
612-626-2505

Administrative Email
jhutchin@umn.edu

Assistant Professor of Medicine, Cardiovascular Division


PhD, Biophysics, Johann Wolfgang Goethe Universitaet, Frankfurt am Main, Germany

MS, Biophysics, Nankai University, Tianjin, China

Bs, Biophysics, Nankai University, Tianjin, China

Summary

I have a broad background in physiology, with specific training and expertise in research areas such as ion channel mechanisms and patch clamp electrophysiology. For my postdoctoral projects, I carried out electrophysiological experiments to study nicotinic acetylcholine receptors at neuromuscular junctions, voltage-gated cardiac sodium channel and other cardiac ion channels. I have developed a sophisticated understanding of cardiac physiology and experience working with acutely isolated/cultured cardiomyocytes and human iPSC-derived cardiomyocytes. I have published papers in Circulation Research “Cardiac Na+ current regulation by pyridine nucleotides” and “Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel” to study how NADH-induced metabolic stress downregulates cardiac Na+ channel and how NAD+ reverses the channel changes. Recently, I am focusing on studying the regulation of the unfolded protein response on cardiac ion channels in cardiomyopathy, to elucidate the underlying cellular mechanism for the integrated phenotypes at the organ and animal levels.

Expertise

  • Electrophysiology
  • Metabolic regulation of cardiac ion channels

Research

Research Summary/Interests

cardiac ion channels under ER stress and the activated unfolded protein response; UPR and arrhythmias;

Research Funding Grants

Active Grants
Rhode Island Foundation

Publications

  • Liu M., Sanyal S., Gao G., Gurung I.S., Zhu X., Gaconnet G., Kerchner L.J., Shang L.L., Huang C.L.H., Grace A., London B., Dudley S.C., Jr. Cardiac Na+ current regulation by pyridine nucleotides, Circ. Res., 105(8), 737-745, 2009. 
  • Liu M., Liu H., Dudley S.C., Jr. Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel, Circ Res., 107(8), 967-974, 2010.
  • Liu M., Gu L., Sulkin M.S., Liu H., Jeong E-M., Greener I., Xie A., Efimov I.R., Dudley S.C., Jr. Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy. J Mol Cell Cardiol., 54: 25-34, 2013.
  • Gao G., Xie A., Zhang J., Herman A.M., Jeong E-M., Gu L., Liu M., Yang K-C., Kamp T.J., Dudley, S.C., Jr. The unfolded protein response regulates cardiac sodium current in systolic human heart failure. Circ Arrhythm Electrophysiol., 6(5):1018-1024, 2013.
  • Liu M., Yang K-C., Dudley S.C., Jr. Cardiac sodium channel mutations: Why so many phenotypes? Nat Rev Cardiol., 2014, 11:607-615.
  • Liu M., Dudley S.C., Jr. Targeting the unfolded protein response in heart diseases. Expert Opin Ther Targets, 2014, 18(7):719-723.
  • Liu M., Dudley S.C., Jr. Role for the unfolded protein response in heart failure and cardiac arrhythmias, Int. J. Mol. Sci, 2016, 17:52.
  • Liu M., Shi G., Yang K-C., Gu L., Dudley S.C., Jr. The role of PKC in the metabolic regulation of the cardiac Na+ channel, Heart Rhythm, 14(3):440-447, 2017.

Teaching

Academic Interests and Focus

Physiology; Medical Biophysics

Clinical

Clinical Interests

Arrhythmia; heart failure; MI