Lin Yee Chen, MD, MS

Associate Professor of Medicine, Cardiovascular Division

Lin Yee Chen

Contact Info

Office Address:
Cardiovascular Division
Variety Club Research Center
401 East River Parkway
2nd Floor
Minneapolis, Minnesota 55455

Mailing Address:
UMN – Cardiovascular Division
420 Delaware Street SE
MMC 508 Mayo
8508A (Campus Delivery Code)
Minneapolis, MN 55455

Administrative Assistant Name
Wendy

Administrative Phone
612-625-4401

Administrative Email
marku002@umn.edu

Administrative Fax Number
612-626-4411

Associate Professor of Medicine, Cardiovascular Division

Co-Director, Atrial Fibrillation Center, University of Minnesota Health Heart Care

Medical Director, Cardiac Electrophysiology Laboratory, University of Minnesota Medical Center

Chair, 2018 AHA Scientific Statement Writing Group: Atrial Fibrillation Burden—Moving Beyond Atrial Fibrillation as a Binary Entity


Cardiac Electrophysiologist, Cardiologist


Medical School, National University of Singapore, Singapore

Internal Medicine Residency, Mayo Clinic, Rochester, MN

Cardiology and Cardiac Electrophysiology Fellowship, Mayo Clinic, Rochester, MN

Master of Science in Clinical Research, University of Minnesota, Minneapolis, MN

Summary

I am a tenured Associate Professor of Medicine, an ABIM board-certified cardiac electrophysiologist, and an NIH-funded clinical investigator. My research on atrial fibrillation (AF) is focused on 2 themes: (1) To discover novel strategies to prevent AF, reduce AF burden, and prevent AF-related outcomes, and (2) To characterize the relationship of AF to outcomes such as stroke, dementia, and sudden cardiac death, and to elucidate the underlying mechanisms. As an Atherosclerosis Risk in Communities (ARIC) and Multi-Ethnic Study of Atherosclerosis (MESA) investigator, I have published and co-authored numerous papers on AF using ARIC and MESA data. Currently, I am the PI of 2 NIH R01-funded projects: (1) a large multi-center project (R01HL126637) that uses the Zio XT Patch—an ambulatory heart rhythm monitor—to define the prevalence of subclinical AF in the elderly and elucidate the prognostic significance of subclinical AF and AF burden, (2) R01HL141288 which aims to clarify the role of underlying left atrial abnormality in determining AF-related related stroke and cognitive decline. Clinically, I provide comprehensive, evidence-based, and state-of-the-art care to patients with AF which includes performing catheter ablation to maintain sinus rhythm and left atrial appendage occlusion to prevent cardioembolic stroke.

Awards & Recognition

  • American Heart Association, 10SDG3420031, 2010-2015, Gene-Gene and Gene-Environment Interactions in Atrial Fibrillation
  • National Institute on Aging, R21AG042660, 2013-2016, Arterial Structure and Function and Atrial Fibrillation
  • National Heart, Lung, and Blood Institute, R01HL126637, 2016-2021, Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly
  • AHC Faculty Research Development Award, 2017-2019, Moderate-Intensity Continuous Training and Sprint Interval Training in Reducing Atrial Fibrillation Burden
  • National Heart, Lung, and Blood Institute, R01HL141288, 2018-2022, Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline

Professional Associations

  • Member - Management Committee, Cardiovascular Service Line, University of Minnesota Health Heart Care
  • Member - ECG & Arrhythmias Committee, Clinical Cardiology Council, American Heart Association
  • Member - Research Committee, Heart Rhythm Society
  • Member - Evidence Review Committee for the AHA/ACC 2016 Guideline for the Treatment of Syncope
  • Member - 2017 ACC/AHA/Heart Rhythm Society Guideline Focused Update on the Management of Patients With Atrial Fibrillation Writing Committee
  • Member - 2018 EHRA/HRS/APHRS/SOLAECE Expert Consensus on Arrhythmias and Cognitive Function: What is the best practice?

Research

Research Summary/Interests

Care Philosophy
I believe in providing comprehensive and evidence-based cardiac electrophysiology care to my patients.

Research Funding Grants

Principal Investigator

  • NIH R01 HL126637 (2016-2021): Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly
  • NIH R01 HL141288 (2018-2022): Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
  • Academic Health Faculty Research Development Grant (2017-2019): Moderate-Intensity Continuous Training and Sprint Interval Training in Reducing Atrial Fibrillation Burden

Co-Investigator

  • NIH R01 HL127659 (2015-2019): Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESA
  • NIH R01 HL122200 (2015-2018): Comparative Effectiveness of Oral Anticoagulants in Atrial Fibrillation
  • NIH R21 AG058445 (2017-2019): Atrial fibrillation treatment in older adults

Publications

Chen LY, Chung MK, Allen LA, Ezekowitz M, Furie KL, McCabe P, Noseworthy PA, Perez MV, Turakhia MP. Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity. Circulation 2018: doi:10.1161/CIR.0000000000000568

Bekwelem W, Norby FL, Agarwal SK, Matsushita K, Coresh J, Alonso A, Chen LY, Association of Peripheral Artery Disease with Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study. JAHA 2018; 7:e007452.

Chen LY, Norby FL, Gottesman RF, Mosley TH, Soliman EZ, Agarwal SK, Loehr LR, Folsom AR, Coresh J, Alonso A. Atrial fibrillation and its association with cognitive decline and dementia over 20 years: The Atherosclerosis Risk in Communities neurocognitive study (ARIC-NCS). JAHA 2018 Mar 7;7(6):e007301.

Maheshwari A, Norby FL, Soliman EZ, Koene R, Roonery M, O’neal WT, Alonso A, Chen LY. Refining Prediction of Atrial Fibrillation Risk in the General Population With Analysis of P-Wave Axis (from the Atherosclerosis Risk In Communities Study). Am J Cardiol 2017 Dec 1;120(11);1980-1984.

Alonso A, Knopman DS, Gottesman RF, Soliman EZ, Shah AJ, O’Neal WT, Norby FL, Mosley TH, Chen LY. Correlates of dementia and mild cognitive impairment in patients with atrial fibrillation: The ARIC-Neurocognitive Study (ARIC-NCS). J Am Heart Assoc 2017;6:e006014.

Maheshwari A, Norby FL, Soliman EZ, Koene RJ, Rooney MR, O'Neal WT, Alonso A, Chen LY. Abnormal P-wave axis and ischemic stroke: The ARIC study (Atherosclerosis Risk In Communities). Stroke 2017;48(8):2060-2065.

Maheshwari A, Norby FL, Soliman EZ, Alraies MC, Adabag S, O'Neal WT, Alonso A, Chen LY. Relation of prolonged P-wave duration to risk of sudden cardiac death in the general population (from the Atherosclerosis Risk in Communities Study). Am J Cardiol 2017 May 1;119(9):1302-1306.

Chang IC, Agamawi YM, Austin E, Adkisson WO, Roukoz H, von Wald LN, Sakaguchi S, Benditt DG, Chen LY. Usefulness of atrial fibrillation as a marker for adverse cardiovascular outcomes in both primary and secondary prevention in patients with implantable cardioverter-defibrillators. Am J Cardiol 2016 Nov 15;118(10):1497-1502.

Bekwelem W, Jensen PN, Norby FL, Soliman EZ, Agarwal SK, Lip GY, Pan W, Folsom AR, Longstreth WT Jr, Alonso A, Heckbert SR, Chen LY. Carotid atherosclerosis and stroke in atrial fibrillation: The Atherosclerosis Risk in Communities study. Stroke 2016 Jun;47(6):1643-6.

Chen LY, Leening MJ, Norby FL, Roetker NS, Hofman A, Franco OH, Pan W, Polak JF, Witteman JC, Kronmal RA, Folsom AR, Nazarian S, Stricker BH, Heckbert SR, Alonso A. Carotid intima-media thickness and arterial stiffness and the risk of atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study, Multi-Ethnic Study of Atherosclerosis (MESA), and the Rotterdam study. J Am Heart Assoc 2016 May 20;5(5).

Chen LY, Agarwal SK, Norby FL, Gottesman RF, Loehr LR, Soliman EZ, Mosley TH, Folsom AR, Coresh J, Alonso A. Persistent but not paroxysmal atrial fibrillation is independently associated with lower cognitive function: ARIC study. J Am Coll Cardiol 2016 Mar 22;67(11):1379-80.

Chen LY, Bigger JT, Hickey KT, Chen H, Lopez-Jimenez C, Banerji MA, Evans G, Fleg JL, Papademetriou V, Thomas A, Woo V, Seaquist ER, Soliman EZ. Effect of intensive blood-pressure lowering on incident atrial fibrillation and P-wave indices in the ACCORD blood-pressure trial. Am J Hypertens 2015 Oct 16. pii:hpv172.

Alonso A, MacLehose RF, Lutsey PL, Konety S, Chen LY. Association of amiodarone use with acute pancreatitis in patients with atrial fibrillation: A nested case-control study. JAMA Intern Med 2015 Mar;175(3):449-50.

Chen LY, Lopez FL, Gottesman RF, Huxley RR, Agarwal SK, Loehr L, Mosley T, Alonso A. Atrial fibrillation and cognitive decline: The role of subclinical cerebral infarcts: The Atherosclerosis Risk in Communities study. Stroke 2014 Sep;45(9):2568-74.

Chen LY, Sotoodehnia N, B?žková P, Lopez FL, Yee LM, Heckbert SR, Prineas R, Soliman EZ, Adabag S, Konety S, Folsom AR, Siscovick D, Alonso A. Atrial fibrillation and the risk of sudden cardiac death: The Atherosclerosis Risk in Communities study and Cardiovascular Health study. JAMA Intern Med 2013 Jan 14;173(1):29-35.

Clinical

Clinics

University of Minnesota Medical Center;University of Minnesota Physicians Heart at Fairvie

Board Certifications

  • Internal Medicine
  • Cardiology
  • Cardiac Electrophysiology

Clinical Interests

Atrial fibrillation ablation (pulmonary vein isolation); Biventricular ICD implantation; ICD implantation; PVC ablation; Supraventricular tachycardia ablation; Ventricular tachycardia ablation

Hospital Privileges

Fairview Lakes Medical Center; University of Minnesota Health Maple Grove Clinics; Fairview Ridges Hospital; Fairview Southdale Hospital; University of Minnesota Medical Center