Hematology, Oncology and Transplantation
Division of Hematology, Oncology
Adult Blood and Marrow
Zohar Sachs, MD, PhD and David Largaespada, PhD received a Translational Working Group Pilot Award from the Masonic Cancer Center. With the support of this award, Drs. Sachs and Largaespada will investigate the molecular mechanisms that allow leukemia stem cells to evade chemotherapy and reemerge as a malignant tumor. Using a unique mouse model of acute myelogenous leukemia, they will characterize the signaling and transcriptional profiles of leukemia cells that persist in vivo during disease remission by using ultra-high parameter flow cytometry (mass cytometry) and single-cell RNA sequencing. Please join us in congratulating Dr. Sachs and Dr. Largaespada on receipt of this award. Posted December 2014.
Emil Lou, MD, PhD received a Mezin-Koats Colon Cancer Research Award from the Masonic Cancer Center. The Mezin-Koats Colon Cancer Research Award, designed to support research that advances the treatment of colon cancer, will support Dr. Lou and his research team in their efforts to determine whether tunneling nanotubes act as a physical conduit for intercellular transfer of oncogenic KRAS and miRNAs in colon cancer. Long and narrow, tunneling nanotubes are membrane structures that provide a physical channel for the transfer of cellular contents from one cell to another. Dr. Lou’s studies will examine the role of tunneling nanotubes in mediating direct intercellular transfer of oncogenic KRAS and microRNAs and their effects on recipient tumor cells. The ultimate goal of Dr. Lou’s project is to establish a novel biologic mechanism of cancer cell communication that can be targeted with inhibitors of tunneling nanotubes. Please join us in congratulating Dr. Lou and his research team on their receipt of a Mezin-Koats Colon Cancer Research Award. Posted November 2014.
Kalpna Gupta’s work on pain in sickle cell disease was highlighted in a news article published in a November 2014 issue of Nature. The article, titled “Neurobiology: Life beyond the pain,” is part of a special supplemental issue of Nature covering sickle cell disease. Posted November 2014.
Dan Kaufman, MD, PhD was a featured speaker at the 2014 International Stem Cell Forum (ISCF),held in Tianjin, China on November 1-3, 2014 (see photo). Organized by the Chinese Academy of Medical Sciences and several other Chinese research institutes, the ISCF aims to foster international collaborations and multi-disciplinary stem cell research. This year’s ISCF featured internationally renowned stem cell researchers discussing hematopoietic stem cell development and transplantation, along with other topics related to hematopoietic stem cell biology. Dr. Kaufman was the co-chair of the session on stem cell reprogramming and gave a presentation entitled “Use of human pluripotent stem cell-derived blood cells for anti-cancer therapy.” Posted November 2014.