Craig Eckfeldt, MD, PhD
Assistant Professor of Medicine
E: Barbara Porwit
P: (612) 624-5620
F: (612) 625-6919
Division of Hematology, Oncology and Transplantation
420 Delaware Street SE, MMC 480
Minneapolis, MN 55455
Dr. Craig Eckfeldt graduated from the University of Minnesota’s Combined M.D./Ph.D. Program with a Ph.D. in Microbiology, Immunology and Cancer Biology (advisor: Catherine Verfaillie, M.D.) in 2005 and an M.D. in Internal Medicine in 2007. He received the Minnesota Medical Foundation J. Thomas Livermore Award in 2005 and was elected to Alpha Omega Alpha Honor Society in 2006. Dr. Eckfeldt is a graduate of the fellowship program in Hematology, Oncology and Transplantation at the University of Minnesota. He joined the Hematology, Oncology and Transplantation faculty in July 2013.
The goal of the research in our lab is to investigate the genetics and signaling pathways that drive acute myeloid leukemia (AML) to provide a foundation for the development of novel targeted treatment approaches for AML. Our research is focused on identifying the critical mediators of RAS signaling that drive AML growth and survival using molecular genetic approaches in the most clinically relevant genetically engineered mouse models, human AML cell lines, and primary AML patient samples in vitro and in patient-derived AML xenografts. We are evaluating the role of clinically-relevant biochemical signaling pathway inhibitors alone and in combination with novel chemotherapeutic approaches to maximize the translational potential of our studies. We are utilizing cutting-edge multi-parameter flow cytometry and next generation sequencing to characterize AML treatment response and identify potential mechanisms of treatment resistance. In total, these translational studies will provide novel insights for the development of rationally designed targeted therapies for human AML.
- Patterson LJ, Gering M, Eckfeldt CE, Green AR, Verfaillie CM, Ekker SC, Patient R. The transcription factors, Sci and Lmo2 act together during the development of the haemangioblast in zebrafish. Blood 2007; 109:2389-2398.
- Pickart MA, Klee EW, Nielsen AL, Sivasubbu S, Mendenhall EM, Bill BR, Chen E, Eckfeldt CE, Knowlton M, Robu ME, Larson JD, Deng Y, Schimmenti LA, Ellis LBM, Verfaillie CM, Hammerschmidt M, Farber SA, Ekker SC. Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS ONE 2006; 1:e104.
- Eckfeldt CE, Mendenhall EM, Verfaillie CM. The molecular repertoire of the “almighty“ stem cell. Nat Rev Mol Cell Biol 2006; 6:726-737.
- Eckfeldt CE, Mendenhall EM, Flynn CM, Want T, Pickart MA, Grindle SM, Ekker SC, Verfaillie CM. Functional analysis of hematopoietic stem cell gene expression using zebrafish. PLoS Biol 2005; 3:e254.
- Leung AY, Mendenhall EM, Kwan TT, Liang R, Eckfeldt C, Chen E, Hammerschmidt M, Grindley S, Ekker SC, Verfaillie CM. Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev Biol 2005; 277:235-254.
- Hematti P, Hong BK, Ferguson C, Adler R, Hanawa H, Sellers S, Holt IE, Eckfeldt CE, Sharma Y, Schmidt M, von Kalle C, Persons DA, Billings EM, Verfaillie CM, Nienhuis AW, Wolfsberg TG, Dunbar CE, Calmels B. Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol 2004; 2:e423.
- Bertrand FE, Eckfeldt CE, Lysholm AS, LeBien TW. Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells. Leukemia 2000; 14:2095-2102.
- Bertrand FE, Eckfeldt CE, Fink JR, Lysholm AS, Pribyl JA, Shah N, LeBien TW. Microenvironmental influences on human B-cell development. Immunol Rev 2000; 175:175-186.