Carol Lange, PhD
Professor of Medicine
University of Colorado School of Pharmacy
E: Sandi Sherman
P: (612) 626-0671
F: (612) 625-6919
Division of Hematology, Oncology and Transplantation
420 Delaware Street SE, MMC 480
Minneapolis, MN 55455
Dr. Lange is a Professor in the Departments of Medicine and Pharmacology at the University of Minnesota. She received her Ph.D. from the University of Colorado School of Pharmacy in 1991. She holds memberships in The Endocrine Society (Full Member) and Women in Endocrinology. Dr. Lange serves as teaching faculty in the U of MN Department of Pharmacology Graduate Program, Microbiology, Immunology, and Cancer Biology Graduate Program and MD/PhD Combined Program. She has served on several NIH Study Sections including Biochemical Endocrinology and Metabolic Physiology.
Director, Cancer Biology Training Grant (T32), Masonic Cancer Center, University of Minnesota (2010-present)
Director, Cell Signaling Program, Masonic Cancer Center, University of Minnesota
Dr. Lange studies the molecular biology of breast cancer. Her laboratory is focused on the study of cross-talk between peptide growth factors and steroid hormone receptors in human breast cancer cells, with the goal of developing better strategies for the treatment of breast and other hormonally influenced and/or epithelial cell-derived cancers.
- Tickle Family Land Grant Endowed Chair (2009-present)
- Associate Editor, Hormones and Cancer
- Scientific Editor, Endocrine Related Cancer
- Lange CA, Yee D. Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer. Endocr Relat Cancer. 2011 Jul 4;18(4):C19-24. Print 2011.
- Hagan CR, Regan TM, Dressing GE, Lange CA. ck2-Dependent Phosphorylation of Progesterone Receptors (PR) on Ser81 Regulates PR-B Isoform-Specific Target Gene Expression in Breast Cancer Cells. Mol Cell Biol. 2011 Jun;31(12):2439-52.
- Locatelli A, Lange CA. Met Receptors Induce Sam68-dependent Cell Migration by Activation of Alternate Extracellular Signal-regulated Kinase Family Members. J Biol Chem. 2011 Jun 17;286(24):21062-72.
- Dressing GE, Goldberg JE, Charles NJ, Schwertfeger KL, Lange CA. Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications. Steroids. 2011 Jan;76(1-2):11-7.
- Daniel AR, Gaviglio AL, Czaplicki LM, Hillard CJ, Housa D, Lange CA. The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention. Mol Endocrinol. 2010 Nov;24(11):2126-38.
- Ostrander JH, Daniel AR, Lange CA. Brk/PTK6 signaling in normal and cancer cell models. Curr Opin Pharmacol. 2010 Dec;10(6):662-9. Epub 2010 Sep 9. Review.
- Castro NE, Lange CA. Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells. Breast Cancer Res. 2010;12(4):R60.
- Daniel AR, Lange CA. Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14287-92.
- Daniel AR, Knutson TP, Lange CA. Signaling inputs to progesterone receptor gene regulation and promoter selectivity. Mol Cell Endocrinol. 2009 Sep 24;308(1-2):47-52.
- Dressing GE, Hagan CR, Knutson TP, Daniel AR, Lange CA. Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models. Endocr Relat Cancer. 2009 Jun;16(2):351-61.