Medical School

Gastroenterology, Hepatology and Nutrition

Department of Medicine

Alex Khoruts, MD

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Academic Title

Associate Professor of Medicine

Clinical Title

Gastroenterologist

Specializations

  • Gastroenterology (Digestive Health)
  • Endoscopy

Practices

  • Riverside Endoscopy Center -- University of Minnesota Physicians
  • Fairview Maple Grove Medical Center

Education

Medical School
University of Minnesota
Residency
University of Minnesota
Fellowship
University of Minnesota

Administrative Contact

General Information
E: GHN
P: (612) 625-8999
F: (612) 625-5620

Clinic Appointments
P: Main Scheduling Line: (612) 672-7000
P: Physician Referral Line: (612) 672-7575
W: Gastroenterology Clinic

Mailing Address

Division of Gastroenterology, Hepatology, and Nutrition
406 Harvard Street SE, Room V366 VFW Bldg, MMC 36
Minneapolis, MN 55455
 

Bio Statement

Dr. Khoruts has trained at the University of Minnesota. In addition to completing his fellowship in gastroenterology, he also trained in basic immunology as a Howard Hughes Physician Fellow under the mentorship of Dr. Marc Jenkins in the Department of Microbiology. He is active in primary areas of investigation including both basic immunology and translational research.

Research Interests

Active primary areas of investigation include both basic immunology and translational research:

Regulatory Foxp3+ CD4 T cells (Tregs). This subset of T cells is critically involved in maintenance of immunologic tolerance. These cells emerge from the thymus, but may also be induced de novo from mature T cells following exposure to an antigen under specific stimulation conditions. Induction of Tregs may be important in treating autoimmune diseases and encourage tolerance to transplanted organs. The two major questions pursued in the laboratory include mechanisms of Treg induction and the role of Tregs in maintaining diversity of the conventional T cell population.
The role of intestinal microbiota in gastrointestinal disease. A major effort is currently being developed to identify th intestinal microorganisms that may be protective against Clostridium difficile associated disease. Specifically, research is conducted to characterize the microbial composition of the colon before and after bacteriotherapy by way of fecal transfer in patients suffering from recurrent or refractory Clostridium difficile infection. This work is conducted in collaboration with Dr. Michael Sadowsky in the Department of Soil, Water and Climcate and the BioTechnology Institute.
Dr. Khoruts is also involved in a number of collaborative projects with other investigators. Topics include:

Immune reconstitution of the gut-associated immune tissues in patients with HIV infection (PI: Dr. Timothy Schacker).

Effects of diabetes on gastric innervation (PI: Dr. William Kennedy).

 

Publications
  • Winstead, C.J., Fraser, J.M., and A. Khoruts. 2008. Regulatory CD4+CD25_Foxp3+ T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells. J. Immunol. 180:7305-7317.
  • Kang, J., Huddleston, S.J., Fraser, J.M., and A. Khoruts. 2008. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J Leukoc. Biol. 83:1230-1239.
  • Hataye, J., Moon, J.J., Khoruts, A., Reilly, C.S., and M.K. Jenkins. 2006. Naive and memory CD4+ T cell survival controlled by clonal abundance. Science 312:114-116.
  • Hagen, K., Moses, C.T., Drasler, E.F., Podetz-Pedersen, K., Jameson, S.C., and A. Khoruts. 2004. A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J. Immunol. 173:3909-3915.
  • Thorstenson, K.M., and A. Khoruts. 2001. Generation of anergic and potentially immunoregulatory CD25+CD24+ T cells in vivo following induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 188-195.

 

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  • Last modified on November 18, 2013