Alexander Khoruts, MD
Associate Professor of Medicine
- Gastroenterology (Digestive Health)
- University of Minnesota Health Maple Grove Clinics
- University of Minnesota Medical Center, Fairview -- East Bank
- Endoscopy Services (Minnesota Endoscopy Center)
University of Minnesota, Minneapolis, MN
University of Minnesota, Minneapolis, MN (Internal Medicine)
University of Minnesota, Minneapolis, MN (Gastroenterology)
Dr. Khoruts has trained at the University of Minnesota. In addition to completing his fellowship in gastroenterology, he also trained in basic immunology as a Howard Hughes Physician Fellow under the mentorship of Dr. Marc Jenkins in the Department of Microbiology. He continued his early research focus on basic biology of T cells and autoimmunity, but more recently has redirected his efforts into areas of microbiota therapeutics.
Gut microbiota (commensal microbial communities) is integral to the function of the digestive system and entire body physiology. Disruption of gut microbiota by antibiotics can make the body vulnerable to infections like Clostridium difficile. In addition, gut microbiota likely plays important roles in inflammatory bowel disease, development of the immune system, disorders of energy metabolism like diabetes, and gastrointestinal cancer.
Dr. Khoruts is the Medical Director of the University of Minnesota Microbiota Therapeutics Program. This program brings together multiple investigators from across the Medical School and the University. The primary clinical function at this time is treatment of patients with refractory C. difficile infection. However, additional investigational work is ongoing in metabolic syndrome, gastrointestinal malignancies in cystic fibrosis, blood and marrow transplantation, and inflammatory bowel disease.
- Member, American Gastroenterological Association (2000-present) Remove
- Member, American Association of Immunologists (2001-present)
- Member, American Society for Gastrointestinal Endoscopy (2011-present)
- Principal Investigator on several NIH-funded research projects
- Medical Director, University of Minnesota Microbiota Therapeutics Program
- Department of Medicine Young Investigator Award, University of Minnesota (2001-2003)
- Khoruts, A., Dicksved, J., Jansson, J.K., and M.K. Sadowsky. 2010. Changes in the Composition of the Human Fecal Microbiome after Bacteriotherapy for Recurrent Clostridium Difficile-associated Diarrhea. J. Clin. Gastroenterol. 17:335-342.
- Khoruts, A., and M.J. Sadowsky. 2011. Therapeutic transplantation of the distal gut microbiota. Mucosal Immunol. 4:4-7.
- Bakken, J.S., T. Borody, L.J. Brandt, J.V. Brill, D.C. Demarco, M.A. Franzos, C. Kelly, A. Khoruts, T. Louie, L.P. Martinelli, T.A. Moore, G. Russell, C. Surawicz (The Fecal Microbiota Transplantation Workgroup). 2011. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin. Gastroenterol. Hepatol. 9:1044-1049.
- Borody, T.J., and A. Khoruts. 2011. Fecal microbiota transplantation and emerging applications. Nat. Rev. Gastroenterol. Hepatol. 9:88-96.
- Hamilton, M.J., A.R. Weingarden, M.K. Sadowsky*, and A. Khoruts*. 2012. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. 107:761-767. *Authors equal contributors.
- Hamilton, M.J., A.R. Weingarden, T. Unno, A. Khoruts*, and M.K. Sadowsky*. 2013. High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria. Gut microbes. 4:125-135.
- Weingarden, A.R., Hamilton, M.J., Sadowsky, M.J.*, and Khoruts, A.* 2013. Resolution of Severe Clostridium difficile Infection Following Sequential Fecal Microbiota Transplantation. J. Clin. Gastroenterol. *Authors equally contributed.
- Billings, J.L., Dunitz, J.M., McAllister, S., Herzog, T., Bobr, A., and Khoruts, A. 2013. Early Colon Screening of Adult Patients with Cystic Fibrosis Reveals High Incidence of Adenomatous Colon Polyps. J. Clin. Gastroenterol.
- Kelly, C.R., Kunde, S.S., and Khoruts, A. 2013. A How to Guide: Investigational New Drug Application for Fecal Microbiota Transplantation. Clin Gastroenterol Hepatol.
- Weingarden, A.R., Chen, C., Bobr, A., Yao, D., Lu, Y., Nelson, V.M., Sadowsky, M.J.*, and Khoruts, A.* 2014. Microbiota Transplantation Restores Normal Fecal Bile Acid Composition in Recurrent Clostridium difficile Infection. Am J Physiol Gastointestin Liver Physiol. 306:G310-319. *Authors contributed equally.
- Khoruts, A. Faecal microbiota transplantation 2014: Developing human gut microbiota as a class of therapeutics. Nat. Rev. Gastroenterol. Hepatol. 11:79-80.
- Petrof, E.O. and Khoruts, A. 2014. From stool transplants to next-generation microbiota therapeutics. Gastroenterology, 146:1573-1582.
- Shankar, V., Hamilton, M.J., Khoruts, A., Kilburn, A., Unno, T., Paliy, O., and Sadowsky, M.J. 2014. Species and genus level resolution analysis of microbiota in Clostridium difficile patients following fecal microbiota transplantation. Microbiome.
- Khoruts, A., and Weingarden, A.R. 2014. Emergence of fecal microbiota transplantation as an approach to repair disrupted microbial gut ecology. Immunol. Lett.